Efferent innervation of the arteries of human leptome-ninx in arterial hypertension



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Abstract

Structure of the efferent nerve plexuses (adrenergic, acetylcholinestherase- and cholinacetyltranspherase-positive, NO-dependent), was studied in the arteries of human leptomeninx with different diameters. Material was obtained from the corpses of the healthy people and of the patients with initial stages of arterial hypertension (AH). It was shown that the concentrations of cholinergic and adrenergic nerve fibers and varicosities in axon terminal part, innervating the arteries with the diameters ranging from 450 till 100 μm, were not significantly different. In these arteries, NO-ergic plexuses were also detected. In patients with AH, regardless the arterial diameters, the significant increase (up to 15-20%) of adrenergic nerve fiber and varicosity concentrations was found. The changes in cholinergic nerve fiber concentration were found to depend on the vessel diameter: the significant decrease of these parameter was observed only in arteries with the diameter of 100-200 μm. No significant changes in nerve plexus concentration was noticed in the arteries with greater or smaller diameter. In NO-ergic neural conductors, the enzyme activity decreased only in the large arteries, and remained almost unchanged in the small vascular branches. The changes in the vasomotor innervation described in AH, are interpreted as a vasomotor innervation dysfunction of the leptomeninx arteries that may result in the hemodynamic disturbances.

About the authors

V M CHERTOK

Vladivostok State Medical University

Кафедра анатомии человека; Владивостокский медицинский институт; Vladivostok State Medical University

A Ye KOTSIUBA

Vladivostok State Medical University

Кафедра анатомии человека; Владивостокский медицинский институт; Vladivostok State Medical University

Ye V BABICH

Vladivostok State Medical University

Кафедра анатомии человека; Владивостокский медицинский институт; Vladivostok State Medical University

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