Email this article LIVER, KIDNEY AND A LUNG STRUCTURE IN RATS AFTER INTRAVENOUS MAGNETOLI-POSOME ADMINISTRATION
- Authors: Mil'to IV1, Dziuman AN1
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Affiliations:
- Siberian State Medical University, Tomsk
- Issue: Vol 135, No 3 (2009)
- Pages: 63-66
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/402500
- DOI: https://doi.org/10.17816/morph.402500
- ID: 402500
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Abstract
This work examines the effect of magnetoliposomes on the basis of Fe3O4 nanoparticles following different time intervals after their single intravenous injection, on the liver, kidney and lung structure in rats. Sections were stained with hematoxylin and eosin, and Perls method was used to demonstrate Fe+3 ions. It was shown that shortly after intravenous injection of magnetoliposomes, hemodynamic disturbances developed in all the organs studied, which by day 14 were aggrevated by focal necroses and dystrophic changes in the liver and kidneys. Accumulation of nanoparticles in the cells of mononuclear phagocyte system of these organs was demonstrated. Damaging effect of magnetoliposomes on liver, kidney and a lung structure was established, which was caused by ultradisperse Fe3O4 particles contained in them. The consequences of this influence for the rat organism at the time periods exceeding the duration of our experiment, may hardly be predicted.
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About the authors
I V Mil'to
Siberian State Medical University, Tomsk
Email: milto_bio@mail.ru
Кафедра морфологии и общей патологиицентральная научно-исследовательская лаборатория; Сибирский государственный медицинский университет, г. Томск; Siberian State Medical University, Tomsk
A N Dziuman
Siberian State Medical University, Tomsk
Email: dzyman@mail.ru
Кафедра морфологии и общей патологии; Сибирский государственный медицинский университет, г. Томск; Siberian State Medical University, Tomsk
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Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).