MORPHOMETRIC CHARACTERISTICS OF SUBSTANTIA NIGRA CELLULAR STRUCTURES OF THE HUMAN BRAIN



如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

Neurons and glial cells were studied by means of computer-assisted morphometry in the segments of the ventral and dorsal regions of the compact part of the substantia nigra (CPSN) of the brain. The material obtained at autopsy from 6 males and 3 females aged from 52 to 87 years. It was found that in segments of the ventral CPSN region the neuronal cell bodies and nuclei were larger than those in the segments of the dorsal region. The numerical density of neurons and gliocytes in the ventrolateral segment was higher than in the segments of the dorsal region. In the ventromedial segment the glial index was lower than in the segments of the dorsal region. The morphometric differences found between CPSN segments must be taken into account in the assessment of the morphological changes in substantia nigra of the brain, due to both age involution or pathological process.

全文:

受限制的访问

作者简介

V. Sal’kov

Research Center of Neurology

Email: vla-salkov@yandex.ru
Laboratory of Functional Morphochemistry, Department of Brain Research

R. Khudoyerkov

Research Center of Neurology

Email: rolfbrain@yandex.ru
Laboratory of Functional Morphochemistry, Department of Brain Research

D. Voronkov

Research Center of Neurology

Email: neurolab@yandex.ru
Laboratory of Functional Morphochemistry, Department of Brain Research

参考

  1. Труфанов А. Г., Литвиненко И. В. МРС черной субстанции у первичных пациентов с болезнью Паркинсона, ранее не получавших леводопатерапию // Болезнь Паркинсона и расстройства движений: Руководство для врачей. М.: Изд-во «РКИ Соверо пресс», 2014. С. 147-149.
  2. Alladi P. A., Mahadevan A., Yasha T. C. et al. Absence of age-related changes in nigral dopaminergic neurons of Asian Indians: relevance to lower incidence of Parkinson’s disease // Neuroscience. 2009. Vol. 159. P. 236-245.
  3. Cabello C. R., Thune J. J., Pakkenberg H., Pakkenberg B. Ageing of substantia nigra in humans: cell loss may be compensated by hypertrophy // Neuropathol. Appl. Neurobiol. 2002. Vol. 28. P. 283-291.
  4. Chu Y., Kompoliti K., Cochran E. J. et al. Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra // J. Comp. Neurol. 2002. Vol. 450. P. 203-214.
  5. Damier P., Hirsch E.С., Agid Y., Graybiel A. M. The substantia nigra of the human brain. I. Nigrosomes and nigral matrix, a compartmental organization based on calbindin D28k immunohistochemistry // Brain. 1999. Vol. 122, № 8. P. 1421-1436.
  6. Fearnley J. M., Lees A. J. Ageing and Parkinson’s disease: substantia nigra regional selectivity // Brain. 1991. Vol. 114. P. 2283-2301.
  7. Henchcliffe C., Severt W. L. Disease modification in Parkinson’s disease // Drug. Aging. 2011. Vol. 28, № 8. P. 605-615.
  8. Kordower J. H., Olanow C. W., Dodiya H. B. et al. Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease // Brain. 2013. Vol. 136, № 8. P. 2419-2431.
  9. Panickar K. S., Norenberg. M. D. Astrocytes in cerebral ischemic injury: morphological and general considerations // Glia. 2005. Vol. 50, № 4. P. 287-298.
  10. Ross G. W., Petrovitch H., Abbott R. D. et al. Parkinsonian signs and substantia nigra neuron density in decendents elders without PD // Ann. Neurol. 2004. Vol. 56, № 4. P. 532-539.
  11. Rudow G., O’Brien R., Savonenko A. V. et al. Morphometry of the human substantia nigra in ageing and Parkinson’s disease // Acta Neuropathol. 2008. Vol. 115, № 4. P. 461-470.
  12. Zucca F.A., Basso E., Cupaioli F.A. et al. Neuromelanin of the human substantia nigra: an update // Neurotox. Res. 2014. Vol. 25, № 1. P. 13-23.

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Eco-Vector, 2016


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.
##common.cookie##