LIVER AND STELLATE MACROPHAGE STRUCTURAL ORGANIZATION IN THE NEWBORN CBA AND C57BL/6 MICE

Using electron microscopic and morphometric methods, the morphological peculiarities of the liver and ultrastructural characteristics of the stellate macrophages (Kupffer cells) were studied in the newborn mice (n=20) of two opposing lines - CBA and C57Bl/6 under the conditions of a physiological norm. The structural organization of the liver and stellate macrophage ultrastructure are genetically determined. C57Bl/6 mice, as compared to CBA mice, had higher levels of physiological liver regeneration. Interlinear differences were found also in the ultrastructural organization of the stellate macrophages. Thus, in C57Bl/6 mice these cells possessed more developed network of cisterns of the granular endoplasmic reticulum and a greater number of attached ribosomes, reflecting their higher synthetic activity. The contents of the primary lysosomes was also higher in stellate macrophages of animals of this line.

liver, stellate macrophages (Kupffer cells), electron microscopy, newborn CBA and C57Bl/6 mice