MORPHO-FUNCTIONAL CHARACTERISTICS OF CONDUCTING AIRWAYS AND THE RESPIRATORY PORTION OF RAT LUNG UNDER THE CONDITIONS OF INTRATRACHEAL INFECTION FROM THE POSITIONS OF THE NEUROENDOCRINE REGULATION OF REPARATIVE HISTOGENESES

With the use of light and electron microscopy and immunohistochemistry, the morpho-functional changes in the lungs, the hypothalamus and the neurohypophysis were studied in 45 outbred albino male rats 1, 3, 7 and 14 days after the intratracheal infusion of Staphylococcus aureus strains either possessing anti-lactoferrin activity (ALfA +) or lacking it (ALfA –). After the infusion of ALfA + bacteria, the bronchial wall and the respiratory portion of the lungs demonstrated the destructive changes of tissues, sclerosis phenomena, disturbances of regeneration processes (polypoid outgrowth, metaplasia), while in the neurohypophysis a delay in the release of neurosecretion into the blood from the terminals of nonapeptidergic neurosecretory cells took place. These phenomena were not observed after the infection with ALfA – bacteria. The results obtained indicate the disturbances of the structural-functional homeostasis of pulmonary tissues associated with bacterial ALfa, taking place together with the limitations of the hypothalamic neurosecretion.

lung, conducting airways, respiratory portions, hypothalamic neurosecretion