MORPHOLOGICAL PECULIARITIES OF NEUROPEPTIDE Y-ERGIC INNERVATION OF THE HEART IN POSTNATAL ONTOGENESIS



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Neuropeptide Y (NPY)-containing fibers and intramural ganglionic neurons, as well as Y 1 and Y 2 receptors to NPY were detected in the myocardium of rats during postnatal ontogenesis using immunohistochemical methods. The data obtained suggest age-dependent changes of the NPY-mediated heart innervation. The density of NPY-positive fibers was the least in newborn animals and increased during first 20 days of life. Y 1 and Y 2 receptors were found in the heart of newborn and more adult rats. Y 1 receptors were observed in the coronary heart arteries, arterioles and cardiomyocytes from the moment of birth. The density of NPY Y 2 receptors was very low in the cardiac muscle of young (prior to the 2 nd month of age) and adult (up to 1 year-old) rats but substantially increased in aged animals. During the postnatal ontogenesis? all the intramural ganglionic neurons were Y 1-positive and Y 2-negative.

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作者简介

P. Masliukov

Yaroslavl’ State Medical Academy

Email: mpm@yma.ac.ru

A. Yemanuilov

Yaroslavl’ State Medical Academy

A. Bulibin

Yaroslavl’ State Medical Academy

A. Zverev

Kazan’ Federal University

Email: Alekcei5@rambler.ru

T. Anikina

Kazan’ Federal University

Email: Tania57vg1@rambler.ru

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