Email this article MORPHOLOGICAL PECULIARITIES OF NEUROPEPTIDE Y-ERGIC INNERVATION OF THE HEART IN POSTNATAL ONTOGENESIS
- Authors: Masliukov P.M.1, Yemanuilov A.I.1, Bulibin A.V.1, Zverev A.A.2, Anikina T.A.2
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Affiliations:
- Yaroslavl’ State Medical Academy
- Kazan’ Federal University
- Issue: Vol 146, No 6 (2014)
- Pages: 46-50
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398824
- DOI: https://doi.org/10.17816/morph.398824
- ID: 398824
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Abstract
Neuropeptide Y (NPY)-containing fibers and intramural ganglionic neurons, as well as Y 1 and Y 2 receptors to NPY were detected in the myocardium of rats during postnatal ontogenesis using immunohistochemical methods. The data obtained suggest age-dependent changes of the NPY-mediated heart innervation. The density of NPY-positive fibers was the least in newborn animals and increased during first 20 days of life. Y 1 and Y 2 receptors were found in the heart of newborn and more adult rats. Y 1 receptors were observed in the coronary heart arteries, arterioles and cardiomyocytes from the moment of birth. The density of NPY Y 2 receptors was very low in the cardiac muscle of young (prior to the 2 nd month of age) and adult (up to 1 year-old) rats but substantially increased in aged animals. During the postnatal ontogenesis? all the intramural ganglionic neurons were Y 1-positive and Y 2-negative.
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About the authors
P. M. Masliukov
Yaroslavl’ State Medical Academy
Email: mpm@yma.ac.ru
A. I. Yemanuilov
Yaroslavl’ State Medical Academy
A. V. Bulibin
Yaroslavl’ State Medical Academy
A. A. Zverev
Kazan’ Federal University
Email: Alekcei5@rambler.ru
T. A. Anikina
Kazan’ Federal University
Email: Tania57vg1@rambler.ru
References
- Королева С. В. и Ашмарин И. П. Нейропептид Y: многообразие и кажущаяся противоречивость функций. Анализ возможных опосредованных эффектов. Успехи физиол. наук, 2000, т. 31, № 1, с. 31-46.
- Маслюков П. М., Ноздрачев А. Д. и Timmermans J. P. Возрастные особенности нейротрансмиттерного состава нейронов звездчатого узла. Росс. физиол. журн. им. И. М. Сеченова, 2006, т. 92, № 2, с. 214-221.
- Ноздрачев А. Д. и Маслюков П. М. Нейропептид Y и автономная нервная система. Журн. эволюц. биох. и физиол., 2011, т. 47, № 2, с. 105-112.
- Порсева В. В., Шилкин В. В., Корзина М. Б. и др. Особенности возрастных изменений НФ200+-нейронов чувствительных узлов различных сегментарных уровней при химической деафферентации. Морфология, 2012, т. 142, вып. 4, с. 37-42.
- Hodges G. J., Jackson D. N., Mattar L. et al. Neuropeptide Y and neurovascular control in skeletal muscle and skin. Am. J. Physiol. Regulatory Integrative Comp. Physiol., 2009, v. 297, p. 546-555.
- Masliukov P. M. Sympathetic neurons of the cat stellate ganglion in postnatal ontogenesis: morphometric analysis. Auton. Neurosci., 2001, v. 89, № 1-2, p. 48-53.
- Masliukov P. M., Konovalov V. V., Emanuilov A. I. and Nozdrachev A. D. Development of neuropeptide Y-containing neurons in sympathetic ganglia of rats. Neuropeptides, 2012, v. 46, № 6, p. 345-352.
- Michel M. C., Beck-Sickinger A., Cox H. et al. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev., 1998, v. 50, p. 143-150.
- Millar B. C., Schluter K. D., Zhou X. J. et al. Neuropeptide Y stimulates hypertrophy of adult ventricular cardiomyocytes. Am. J. Physiol. Cell Physiol., 1994, v. 266, 5 Pt 1, C1271-C1277.
- Protas L., Barbuti A., Qu J. et al. Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa, L. Circ. Res., 2003, v. 93, p. 972-979.
- Richardson R. J., Grkovic I. and Anderson C. R. Immuno histochemical analysis of intracardiac ganglia of the rat heart. Cell Tissue Res., 2003, v. 314, p. 337-350.
- Rocha-Singh K. J., Matsuo R. and Karliner J. S. Prolonged incubation with neuropeptide Y upregulates beta-adrenoceptors yet does not cause supersensitivity of beta-adrenoceptor signaling. Eur. J. Pharmacol., 1995, v. 288, p. 349-353.
- Zukowska-Grojec Z., Karwatowska-Prokopczuk E., Rose W. et al. Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. Circ. Res., 1998, v. 83, p. 187-195.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).