DISTRIBUTION OF THE MARINESCO BODIES IN THE NEURONS OF HUMAN BRAIN SUBSTANTIA NIGRA



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详细

The aim of the study was to investigate the occurrence and intranuclear distribution of Marinesco bodies in substantia nigra neurons of the human brain. Marinesco bodies were identified in substantia nigra sections of 5 men aged 28 to 58 years old using Nissl staining and immunohistochemical detection of ubiquitin - the protein characteristic of this intranuclear inclusion. Marinesco bodies were found in 1-2% of the substantia nigra neurons, but not in adjacent brain areas. One neuron contained 1-4 Marinesco bodies sized up to 6.7×5.1 μm, which were located both near and at a distance from the nucleolus. Most Marinesco bodies exhibited ubiquitin expression. A trend was found for the increased incidence of Marinesco bodies in human substantia nigra neurons with age.

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作者简介

I. Grigoriyev

RAS Research Institute of Experimental Medicine

Email: ipg-iem@yandex.ru
Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

V. Gusel’nikova

RAS Research Institute of Experimental Medicine

Email: guselnicova.valeriia@yandex.ru
Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

Ye. Sukhorukova

RAS Research Institute of Experimental Medicine

Email: len48@inbox.ru
Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

D. Korzhevskiy

RAS Research Institute of Experimental Medicine

Email: dek2@yandex.ru
Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

参考

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  2. Alladi P. A., Mahadevan A., Vijayalakshmi K. et al. Ageing enhances alpha-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians // Neurochem. Int. 2010. Vol. 57, № 5. P. 530-539.
  3. Dickson D. W., Wertkin A., Kress Y. et al. Ubiquitin immunoreactive structures in normal human brains. Distribution and developmental aspects // Lab. Invest. 1990. Vol. 63. P. 87-99.
  4. Kumada S., Uchihara T., Hayashi M. et al. Promyelocytic leukemia protein is redistributed during the formation of intranuclear inclusions independent of polyglutamine expansion: an immunohistochemical study on Marinesco bodies // J. Neuropathol. Exp. Neurol. 2002. Vol. 61. P. 984-991.
  5. Marinesco G. Sur la presence des corpuscles acidophiles paranucleolaires dans les cellules du locus niger et du locus ceruleus // C. R. Acad. Sci. 1902. Vol. 135. P. 1000-1002.
  6. Morris G. E. The Cajal body // Biochim. Biophys. Acra. 2008. Vol. 1783. P. 2108-2115.
  7. Odagiri S., Tanji K., Mori F. et al. Immunohistochemical analysis of Marinesco bodies, using antibodies against proteins implicated in the ubiquitin - proteasome system, autophagy and aggresome formation // Neuropathology. 2012. Vol. 32. P. 261-266.

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