DEMONSTRATION OF NITRIC OXIDE SYN-THASE IN HUMAN INTRACARDIAC GANGLIA IN NORMAL AND ISCHEMIC MYOCARDIUM



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详细

Nitric oxide synthase (NOS) expression in human intracardiac ganglia was studied using two techniques - histochemical demonstration of NADPH-diaphorase and immunohistochemical staining for NOS1. To detect the influence of coronary heart disease on NOS expression, hearts were studied in patients that died from heart failure (n=8) and in persons that died in accidents (n=3, control). It was found that human intracardiac neurons normally expressed mainly NOS1, and the proportion of these cells amounted to about 40%. A portion of neurons with low and moderate density of staining for NADPH-diaphorase was increased in ischemic myocardium, probably, due NOS2 induction.

作者简介

A SHUKLIN

Russian Cardiologic Scientific Complex, Moscow

Russian Cardiologic Scientific Complex, Moscow

V SHVALYOV

Russian Cardiologic Scientific Complex, Moscow

Russian Cardiologic Scientific Complex, Moscow

参考

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