Intracerebral progression of transplanted rat C6 glioblastoma cells pretreated with neuropeptides and МАРК inhibitor



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详细

The authors have monitored C6 glioma cell invasive growth, proliferation and transcriptional regulation after pretreatment with endothelin-1 and ERK1/2 specific inhibitor PD9S059. To explore proliferation of C6 glioma cells in different growth conditions, they were treated in vitro with endothelin-1 and implanted into the brain. In vitro studies have indicated that PD9S059 inhibited the proliferation of cultured C6 glioma cells and induced the activation of E2F1 and Мус-Max transcriptional factors. Endothelin-1 strongly increased C6 glioma cell prolif-eration. The model used in this study is experimental, but it may provide an insight into the specific behavior of in vitro cultured invasive cells.

作者简介

Z TENCHEVA

Institute of Physiology, Bulgarian Academy of Sciences

Institute of Physiology, Bulgarian Academy of Sciences

I PANOV

University Hospital Losenetz

University Hospital Losenetz

参考

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