Email this article Intracerebral progression of transplanted rat C6 glioblastoma cells pretreated with neuropeptides and МАРК inhibitor
- Authors: TENCHEVA ZS1, PANOV IR2
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Affiliations:
- Institute of Physiology, Bulgarian Academy of Sciences
- University Hospital Losenetz
- Issue: Vol 132, No 6 (2007)
- Pages: 26-30
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/399039
- DOI: https://doi.org/10.17816/morph.399039
- ID: 399039
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Abstract
The authors have monitored C6 glioma cell invasive growth, proliferation and transcriptional regulation after pretreatment with endothelin-1 and ERK1/2 specific inhibitor PD9S059. To explore proliferation of C6 glioma cells in different growth conditions, they were treated in vitro with endothelin-1 and implanted into the brain. In vitro studies have indicated that PD9S059 inhibited the proliferation of cultured C6 glioma cells and induced the activation of E2F1 and Мус-Max transcriptional factors. Endothelin-1 strongly increased C6 glioma cell prolif-eration. The model used in this study is experimental, but it may provide an insight into the specific behavior of in vitro cultured invasive cells.
Keywords
About the authors
Z S TENCHEVA
Institute of Physiology, Bulgarian Academy of SciencesInstitute of Physiology, Bulgarian Academy of Sciences
I R PANOV
University Hospital LosenetzUniversity Hospital Losenetz
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Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).