Localization of bcl-2 antiapoptotic protein in human placenta



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The aim of this investigation was to study the distribution of bcl-2 antiapoptotic protein in various structures of human pla-centa using immunocytochemical methods. Syncytiotrophoblast was found to have the greatest bcl-2 immunorcactivity, while cytotrophoblastic elements, connective tissue cells of the villi and the blood vessel walls were bcl-2-negative. It is suggested that accumulation of bcl-2 in the syncytiotrophoblast may reflect its high resistance to detrimental factors.

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作者简介

D KORZHEVSKIY

RAMS Scientific Research Institute of Experimental Medicine

Отдел морфологии; Институт экспериментальной медицины РАМН; RAMS Scientific Research Institute of Experimental Medicine

V OTELLIN

RAMS Scientific Research Institute of Experimental MedicineRAS LP. Pavlov Institute of Physiology

Отдел морфологиилаборатория онтогенеза нервной системы; Институт экспериментальной медицины РАМНИнститут физиологииим. И.П. Павлова РАН; RAMS Scientific Research Institute of Experimental MedicineRAS LP. Pavlov Institute of Physiology

A STARORUSSKAYA

D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

3лаборатория физиологии и патофизиологии плода; Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН; D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

N PAVLOVA

D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

3лаборатория физиологии и патофизиологии плода; Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН; D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

参考

  1. Коржевский Д.Э., Талантова О.Е. и Павлова Н.Г. Экспрессия белка bcl-2 в развивающемся головном мозге человека. Морфология, 2002, т. 122, вып. 5, с. 31-34.
  2. Нu R, Zhou S. and Li. X. Altered Bcl-2 and Bax expression is associated with cultured first trimester human cytotrophoblasts apoptosis induced by hypoxia. Life Sci, 2006, v. 79, №4, p. 351-355.
  3. Ishihara N.. Matsuo H., Murakoshi H. et al. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation. Am. J. Obstet. Gynecol., 2002, v. 186, № 1, p. 158-166.
  4. Schiessl В., Mylonas I., Hantschmann P. Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies. J. Histochem. Cytochem., 2005, v. 53, № 12, p. 1441-1449.
  5. Straszewski-Chavez S.L., Abrahams V.M. and Мог G. The role of apoptosis in the regulation of trophoblast survival and dif-ferentiation during pregnancy. Endocr Rev., 2005, v. 26, № 7, p. 877-897.
  6. Walensky L.D. Bcl-2 in the crosshairs: tipping the balance of life and death. Cell Death. Differ., 2006, v. 13, № 8, p. 1339-1350.

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