Localization of bcl-2 antiapoptotic protein in human placenta



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Abstract

The aim of this investigation was to study the distribution of bcl-2 antiapoptotic protein in various structures of human pla-centa using immunocytochemical methods. Syncytiotrophoblast was found to have the greatest bcl-2 immunorcactivity, while cytotrophoblastic elements, connective tissue cells of the villi and the blood vessel walls were bcl-2-negative. It is suggested that accumulation of bcl-2 in the syncytiotrophoblast may reflect its high resistance to detrimental factors.

About the authors

D E KORZHEVSKIY

RAMS Scientific Research Institute of Experimental Medicine

Отдел морфологии; Институт экспериментальной медицины РАМН; RAMS Scientific Research Institute of Experimental Medicine

V A OTELLIN

RAMS Scientific Research Institute of Experimental MedicineRAS LP. Pavlov Institute of Physiology

Отдел морфологиилаборатория онтогенеза нервной системы; Институт экспериментальной медицины РАМНИнститут физиологииим. И.П. Павлова РАН; RAMS Scientific Research Institute of Experimental MedicineRAS LP. Pavlov Institute of Physiology

A N STARORUSSKAYA

D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

3лаборатория физиологии и патофизиологии плода; Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН; D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

N G PAVLOVA

D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

3лаборатория физиологии и патофизиологии плода; Научно-исследовательский институт акушерства и гинекологии им. Д.О. Отта РАМН; D.O. Ott RAMS Scientific Research Institute of Obstetrics and Gynecology

References

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  4. Schiessl В., Mylonas I., Hantschmann P. Expression of endothelial NO synthase, inducible NO synthase, and estrogen receptors alpha and beta in placental tissue of normal, preeclamptic, and intrauterine growth-restricted pregnancies. J. Histochem. Cytochem., 2005, v. 53, № 12, p. 1441-1449.
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