MORPHO-FUNCTIONAL IMPLICATIONSOF BETA-AMYLOID APPLICATION ONTOTHE GOLDFISH MAUTHNER CELLS



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详细

The influence of aggregated beta-amyloid peptide fragment
25-35 application on three-dimensional structure and volume
of Mauthner cells (MCs), as determined by reconstruction from
serial histological sections, and on goldfish motor asymmetry was studied. It was shown that in intact and control goldfish motor
asymmetry was stable and strongly correlated with structural
asymmetry of neurons. But under the influence of beta-amyloid, motor asymmetry appeared to be strongly changed or inverted, did not correlate with structural asymmetry and frequently even
was opposite to it. This resulted from strong dystrophy or, on the contrary, hypertrophy of individual neurons and their separate
dendrites with the change in the proportions between them. It is suggested that injurious effect of beta-amyloid peptide on MCs structure, discordant with (irregular) fish behavior, could be the result of mechanical deformation, induced by ribbon-like fibrils
of amyloid peptide. These findings collectively suggest that MCs are the adequate object for the study of the structural aspects of amyloidosis.

作者简介

N Kokanova

Email: kokanchik@rambler.ru

G Mikhaylova

Email: gmikhailova@rambler.ru

R Shtanchaev

Email: rshtanch@mail.ru

N Tiras

Email: ntiras@rambler.ru

E Bezgina

Email: Bezgina@mail.ru

D Moshkov

Email: d_moshkov@mail.ru

N Kokanova

RAS Institute of Theoreticaland Experimental Biophysics

RAS Institute of Theoreticaland Experimental Biophysics

G Mikhailova

RAS Institute of Theoreticaland Experimental Biophysics

RAS Institute of Theoreticaland Experimental Biophysics

R Shtanchayev

RAS Institute of Theoreticaland Experimental Biophysics

RAS Institute of Theoreticaland Experimental Biophysics

N Tiras

RAS Institute of Theoreticaland Experimental Biophysics

RAS Institute of Theoreticaland Experimental Biophysics

Ye Bezgina

RAS Institute of Theoreticaland Experimental Biophysics

RAS Institute of Theoreticaland Experimental Biophysics

D Moshkov

RAS Institute of Theoreticaland Experimental Biophysics

RAS Institute of Theoreticaland Experimental Biophysics

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