MORPHO-FUNCTIONAL CHANGES OF FROURINARY BLADDER RECEPTORS UNDERTHE INFLUENCE OF BARBITURATES



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详细

The effect of hexenal and nembutal on the tissue bushy receptors
was studied the living isolated frog urinary bladder using
methylene blue staining. These drugs were shown to induce
the changes in the receptor pulse activity which included three
phases: an initial sharp increase, an abrupt decline and a low protracted plateau. Reactions to hexenal and nembutal, while
possessing some common features, had their own peculiarities.
Synchronously, the dynamics of methylene blue staining of the receptor elements was registered for the control of the intensity
of oxidation-reduction processes in the receptor neuroplasm, that is for redox-system dynamics. It was found that the phases
of this dynamics coincided in many respects with the phases of the receptor electric activity changes. No ultrastructural changes
associated with the putative damaging effect of barbiturates on the receptors were recorded (during the exposure of 1-30 min).
The most significant characteristic was an accumulation glycogen
granules in the neuroplasm of the receptor elements, suggesting
the prevalence of energy substrate deposition over its expenditure. Depression of the receptor pulse activity supports
the assumption that barbiturates, besides their soporific and narcotic
actions, apparently possess some anesthetic property.

作者简介

V Lukashin

V Vshivtseva

V Lukashin

RAS I.P. Pavlov Institute of Physiology

RAS I.P. Pavlov Institute of Physiology

V Vshyvtseva

RAS I.P. Pavlov Institute of Physiology

RAS I.P. Pavlov Institute of Physiology

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