Email this article MORPHO-FUNCTIONAL CHANGES OF FROURINARY BLADDER RECEPTORS UNDERTHE INFLUENCE OF BARBITURATES
- Authors: Lukashin VG1, Vshivtseva VV1, Lukashin VG2, Vshyvtseva VV2
-
Affiliations:
- RAS I.P. Pavlov Institute of Physiology
- Issue: Vol 136, No 6 (2009)
- Pages: 48-52
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/399206
- DOI: https://doi.org/10.17816/morph.399206
- ID: 399206
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Abstract
The effect of hexenal and nembutal on the tissue bushy receptors
was studied the living isolated frog urinary bladder using
methylene blue staining. These drugs were shown to induce
the changes in the receptor pulse activity which included three
phases: an initial sharp increase, an abrupt decline and a low protracted plateau. Reactions to hexenal and nembutal, while
possessing some common features, had their own peculiarities.
Synchronously, the dynamics of methylene blue staining of the receptor elements was registered for the control of the intensity
of oxidation-reduction processes in the receptor neuroplasm, that is for redox-system dynamics. It was found that the phases
of this dynamics coincided in many respects with the phases of the receptor electric activity changes. No ultrastructural changes
associated with the putative damaging effect of barbiturates on the receptors were recorded (during the exposure of 1-30 min).
The most significant characteristic was an accumulation glycogen
granules in the neuroplasm of the receptor elements, suggesting
the prevalence of energy substrate deposition over its expenditure. Depression of the receptor pulse activity supports
the assumption that barbiturates, besides their soporific and narcotic
actions, apparently possess some anesthetic property.
was studied the living isolated frog urinary bladder using
methylene blue staining. These drugs were shown to induce
the changes in the receptor pulse activity which included three
phases: an initial sharp increase, an abrupt decline and a low protracted plateau. Reactions to hexenal and nembutal, while
possessing some common features, had their own peculiarities.
Synchronously, the dynamics of methylene blue staining of the receptor elements was registered for the control of the intensity
of oxidation-reduction processes in the receptor neuroplasm, that is for redox-system dynamics. It was found that the phases
of this dynamics coincided in many respects with the phases of the receptor electric activity changes. No ultrastructural changes
associated with the putative damaging effect of barbiturates on the receptors were recorded (during the exposure of 1-30 min).
The most significant characteristic was an accumulation glycogen
granules in the neuroplasm of the receptor elements, suggesting
the prevalence of energy substrate deposition over its expenditure. Depression of the receptor pulse activity supports
the assumption that barbiturates, besides their soporific and narcotic
actions, apparently possess some anesthetic property.
Keywords
About the authors
V G Lukashin
V V Vshivtseva
V G Lukashin
RAS I.P. Pavlov Institute of PhysiologyRAS I.P. Pavlov Institute of Physiology
V V Vshyvtseva
RAS I.P. Pavlov Institute of PhysiologyRAS I.P. Pavlov Institute of Physiology
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