Somatometric and Bioimpedance Parameters in the Assessment of Physical Development in Patients with Esophageal Cancer

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论证食管癌是一种临床过程极其凶险、预后较差的恶性肿瘤。其高死亡率凸显了在人群中开展预防性筛查、扩大相关危险因素研究的必要性。在此背景下，研究食管癌患者的体格发育特征具有重要意义。

目的：评估食管癌患者的体测学和生物电阻抗测量特征。

材料与方法。对86例食管癌确诊患者进行人体测量与生物电阻抗分析。测量项目包括身高、体重、肩宽、骨盆宽、腰围、臀围，并计算体重指数和J.M. Tanner性别二态性指数。生物电阻抗测量在АВС01-036型软硬件系统（“Medass”，俄罗斯）上进行。测量内容包括身体成分及相位角数值。相位角可反映机体代谢活性，常用作肿瘤患者的预后指标。对所得结果进行统计学处理，采用描述性统计方法。使用了Shapiro–Francia检验、Kolmogorov–Smirnov检验、Kruskal–Wallis检验、Fisher F检验及Pearson卡方检验。 以p < 0.05为差异显著性标准。

结果。多数患食管鳞状细胞癌的女性患者和患食管腺癌的男性患者体重处于正常范围。在确诊为食管癌的男性患者中，以中等体型为主，并出现向女性型体型偏移的性别逆转趋势（p = 0.001）。在女性食管癌患者中，也以中等体型为主（p = 0.001）。在接受检查的食管癌患者中，依据体型分类，其生物电阻抗指标之间未发现统计学显著差异。相位角在食管癌患者中普遍低于俄罗斯参考值，且与肿瘤分期无关，提示其可能是判断该病不良预后的潜在标志物。

结论。食管腺癌患者通常不存在体重不足。总体上，食管癌患者以中体型为主，男性表现出体型女性化趋势，且其相位角普遍降低，与肿瘤分期无关。

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作者简介

Sergey S. Startsev

Sakhalin Regional Clinical Oncology Center; Pacific State Medical University

Email: sakhstar2010@mail.ru
ORCID iD: 0009-0003-0749-0778
SPIN 代码: 6223-7575
俄罗斯联邦, Yuzhno-Sakhalinsk; Vladivostok

Ekaterina A. Gorbunova

Professor Voino-Yasenetsky Krasnoyarsk State Medical University; Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary

编辑信件的主要联系方式.
Email: opium-100@yandex.ru
ORCID iD: 0000-0002-5297-5980
SPIN 代码: 8525-7253

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Krasnoyarsk; Krasnoyarsk

Anna A. Danilova

Professor Voino-Yasenetsky Krasnoyarsk State Medical University

Email: anya.danilova.02@list.ru
ORCID iD: 0009-0006-1412-8066
SPIN 代码: 4287-1951
俄罗斯联邦, Krasnoyarsk

Nadezhda N. Medvedeva

Professor Voino-Yasenetsky Krasnoyarsk State Medical University

Email: medvenad@mail.ru
ORCID iD: 0000-0002-7757-6628
SPIN 代码: 6144-1780

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Krasnoyarsk

Ruslan A. Zukov

Professor Voino-Yasenetsky Krasnoyarsk State Medical University; Kryzhanovsky Krasnoyarsk Regional Clinical Oncology Dispensary

Email: zukov_rus@mail.ru
ORCID iD: 0000-0002-7210-3020
SPIN 代码: 3632-8415

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Krasnoyarsk; Krasnoyarsk

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2. Fig. 1. Male patients — frequency of major somatotypes according to J.M. Tanner; SDI — sexual dimorphism index.

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3. Fig. 2. Female patients — frequency of somatotypes according to J.M. Tanner; SDI — sexual dimorphism index.

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