Email this article INTERCELLULAR JUNCTION PROTEIN BETA-CATENIN IN NEURONS OF THE RAT BRAIN HABENULA
- Authors: Nazarenkova A.V.1, Kirik O.V.1, Korzhevskiy D.E.1,2
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Affiliations:
- Institute of Experimental Medicine
- St. Petersburg State University
- Issue: Vol 150, No 5 (2016)
- Pages: 63-65
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/397739
- DOI: https://doi.org/10.17816/morph.397739
- ID: 397739
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Abstract
The study was carried out on frontal sections of the Wistar rat brain (n=5) with the use of immunocytochemical methods. For the first time beta-catenin was found in the nuclei of mature neurons of the medial part of habenula. Since intranuclear localization of this protein indicates its involvement in the canonical Wnt signaling pathway, which is normally realized in embryogenesis, it is suggested that habenular neurons retain the properties that are not characteristic of mature neurons.
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About the authors
A. V. Nazarenkova
Institute of Experimental Medicine
Email: iemmorphol@yandex.ru
O. V. Kirik
Institute of Experimental Medicine
Email: olga_kirik@mail.ru
D. E. Korzhevskiy
Institute of Experimental Medicine; St. Petersburg State University
Email: dek2@yandex.ru
References
- Алексеева О. С., Гусельникова В. В., Безнин Г. В., Коржевсий Д. Э. Перспективы использования ядерного белка NeuN в качестве показателя функционального состояния нервных клеток у позвоночных // Журн. эволюц. биохим. 2015. Т. 51, № 5. С. 313-323.
- Кирик О. В., Алексеева О. С., Коржевский Д. Э. Экспрессия маркера нейральных стволовых клеток Msi-1 в конечном мозгу крысы // Морфология. 2011. Т. 139, вып. 2. С. 77-79.
- Chao J., Yang L., Yao H., Buch S. Platelet-derived growth afctor-BB restores HIV Tat-mediated impairment of neurogenesis: role of GSK-3β/β-catenin // J. Neuroimmune Pharmacol. 2014. Vol. 9, № 2, P. 259-268.
- Wagner F., Stroh T., Veh R. Correlating habenular subnuclei in rat and mouse by using topographic, morphological and cytochemical criteria // J. Comp. Neurol. 2014. Vol. 522. P. 2650-2662.
- Wisniewska M. Physiological role of beta-catenin /TCF signaling in neurons of the adult brain // Neurochem. Res. 2013. Vol. 38, № 6. P. 1144-1155.
- Zechner D., Fujita Y., Hulsken J. et al. β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system // Dev. Biol. 2003. Vol. 258. P. 406-418.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).