DYNAMICS OF THE EXPRESSION OF IONOTROPIC GLUTAMATE RECEPTOR GLUR2 SUBUNIT IN THE VENTROLATERAL PART OF A SOLITARY TRACT NUCLEUS IN THE EARLY POSTNATAL PERIOD IN NORM AND IN PRENATAL SEROTONIN DEFICIENCY



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Abstract

In the experiments on Wistar rats (n=18), the dynamics of ionotropic glutamate receptor GluR2 subunit expression was studied in respiratory subnuclei (ventral and lateral) of the solitary tract nucleus (STN). The observations were performed in the early postnatal period (days 5, 10 and 20; 5-6 animals in each group) in norm and after prenatal serotonin depletion, which was achieved by inhibition a tryptophan hydroxylase by para-chlorophenylalanine. Immunocytochemical demonstration of GluR2 has shown that its expression was approximately equal in both respiratory subnuclei during the early postnatal period. By the juvenile age, there was a significant increase of GluR2 expression (2-fold in lateral subnuclei and 2,6-fold in ventral subnuclei). Prenatal serotonin deficiency changed the expression of GluR2 in respiratory subnuclei of STN. In the early postnatal period, the significant delay of GluR2 expression, that raised to control values by the second postnatal week, however by juvenile age the expression of GluR2 was twice lower than in the control. Disturbances of glutamatergic receptor network in the respiratory subnuclei can be the basis for the respiratory dysfunctions.

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L. I. Khozhai

RAS I. P.Pavlov Institute of Physiology

Email: astarta0505@mail.ru
Laboratory of the Nervous System Ontogenesis

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