Email this article THE CHANGES IN THE LUNG STRUCTURE AND MATRIX METALLOPROTEINASE 9 EXPRESSION IN RATS UNDER THE INFLUENCE OF OXYTOCIN IN THE COMBINED STRESS
- Authors: Kozlova A.N.1
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Affiliations:
- Orenburg State Medical University
- Issue: Vol 152, No 5 (2017)
- Pages: 54-60
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398151
- DOI: https://doi.org/10.17816/morph.398151
- ID: 398151
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Abstract
Using light, electron microscopy and immunohistochemistry, the changes in lung structure and matrix metalloproteinase 9 (MMP 9) expression were studied in 30 rats exposed to combined stress (intratracheal infusion of E. coli in association with emotional painful stress) and oxytocin (OT) injections. Studies have shown that the combined stress resulted in the increased expression of pulmonary MMP-9, accompanied by the activation of neutrophil and macrophage migration with the destruction of cells and intercellular substance in the lung. In animals treated with OT, the expression of MMP 9 was significantly reduced and was associated with lower levels of destructive changes and the infiltration of the lungs by neutrophils and macrophages. The results obtained suggest the pathogenetic role of MMP 9 in combined stress lesions and its involvement in the regulation of MMP 9 expression in the lungs.
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About the authors
A. N. Kozlova
Orenburg State Medical University
Email: gistolog31@mail.ru
Department of Histology, Cytology, and Embryology
References
- Стадников А. А., Безносик Р. В., Шевлюк Н. Н., Козлова А. Н. Гисто-и цитологические аспекты гипоталамической нейроэндокринной регуляции взаимодействий про-и эукариот, реализуемых в эпителиальных структурах трахеи и бронхов крыс // Вестн. Уральск. мед. акад. науки. 2011. Т. 1. вып. 2. С. 69-70.
- Третьяков А. А., Чумаков А. М. Экспериментально-гистологическое изучение влияния окситоцина на репарацию структур печени и общего желчного протока // Морфология. 2010. Т. 137, вып. 4. С. 192.
- Corbel М., Boichot E., Lagente V. Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury // Braz. J. Med. Biol. Res. 2000. Vol. 33, № 7. P. 749-754.
- Delclaux C., Delacourt C., D’Ortho M. P. et al. Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane // Am. J. Respir. Cell Mol. Biol. 1996. Vol. 14, № 3. P. 288-295.
- Desiderato O., Mac Kinnon J. R., Hisson H. Development of gastric ulcer in rats following stress termination // J. Comp. Physiol. Psychol. 1974. Vol. 87, № 2. P. 208-214.
- Kim J. Y., Choeng H. C., Ahn C., Cho S. H. Early and late changes of MMP-2 and MMP-9 in bleomycin-induced pulmonary fibrosis // Yonsei Med. J. 2009. Vol. 50, № 1. P. 68-77.
- Kolaczkowska E., Plytycz B., Arnold B. et al. Increased cyclooxy genase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9 // Immunology. 2009. Vol. 128, № 1. P. 262-274.
- Lukkarinen H., Hogmalm A., Lappalainen U., Bry K. Matrix metal lo proteinase-9 deficiency worsens lung injury in a model of bron chopulmonary dysplasia // Am. J. Respir. Cell. Mol. Biol. 2009. Vol. 41, № 1. P. 59-68.
- Sasaki M., Kashima M., Ito T. et al. Differential regulation of metallo proteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1beta and TNF-alpha // Mediators Inflamm. 2000. Vol. 9, № 3-4. P. 155-160.
- Szeto A., Nation D. A., Mendez A. J. et al. Oxytocin attenuates NADPH-de pendent superoxide activity and IL-6 secretion in macrophages and vascular cells //Am. J. Physiol. Endocrinol. Metab. 2008. Vol. 295, № 6. P. 1495-1501.
- Tetley T. D. Proteinase imbalance: its role in lung disease // Thorax. 1993. Vol. 48, № 5. P. 560-565.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).