LAMELLAR CORPUSCLES (OF VATER- PACINI) IN HUMAN PANCREAS



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Abstract

Objective - to study the localization and morphogenesis of Pacinian corpuscles (PC) during human pancreatic development, as well in type 2 diabetes mellitus. Materials and methods. Autopsy material was obtained from 42 fetuses and neonates aged from 10th to 40th weeks of gestation and of 65 adults, 18 of whom suffered from type 2 diabetes mellitus. Sections were stained with hematoxylin and eosin and using Mallory method. Immunohistochemical reactions were also performed with markers commonly used to identify PC: antibodies against vimentin, neuron specific enolase (NSE) and S100 protein. A total of more than 1000 sections were examined. Results. PC were shown to be rare finding in the human pancreas: we have detected PC only in one pancreatic section of a newborn with diagnosed diabetic fetopathy. Conclusions. PC cannot play a significant role in the sensory innervation of human pancreas.

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About the authors

A. Ye. Proshchina

Research Institute of Human Morphology

Email: proschina@mtu-net.ru
Laboratory of Nervous System Development 3 Tsurupy St., Moscow 117418

Yu. S. Krivova

Research Institute of Human Morphology

Laboratory of Nervous System Development 3 Tsurupy St., Moscow 117418

Ye. S. Saveliyeva

Research Institute of Human Morphology

Laboratory of Nervous System Development 3 Tsurupy St., Moscow 117418

D. A. Otlyga

Research Institute of Human Morphology

Laboratory of Nervous System Development 3 Tsurupy St., Moscow 117418

S. V. Saveliyev

Research Institute of Human Morphology

Laboratory of Nervous System Development 3 Tsurupy St., Moscow 117418

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