Characteristics of skin histogenesis reparative as affected by the metabolites from Bacillus subtilis 804 culture

Objective - to study the effects of cigarette smoke on the microstructure of rat lung parenchyma. Materials and methods. The study was carried out on 16 rats of two age groups which were daily exposed to tobacco smoke for 20 minutes during 3 months. The characteristics of lung parenchyma microstructure in the experimental and control groups were studied on hematoxylin-eosin stained histological sections. Results. In the experimental animals, pulmonary edema, foci of dystelectasis and partial emphysema, inflammatory infiltration were observed. The bronchial epithelial lining was damaged and had a scalloped appearance. The plethoric vessels, microthrombi, erythrocyte aggregation (sludges), and siderophage accumulation were detected. Control animals showed none of the above-mentioned changes in lung microstructure. Conclusions. The passive smoking affects lung microstructure in albino rats regardless of animal age and duration of exposure to nicotine.

lung, lung parenchymal microstructure, rat, tobacco smoke