PECULIARITIES OF AGE CHANGES OF NF200+-NEURONS IN THE SENSORY GANGLIA OF DIFFERENT SEGMENTAL LEVELS AFTER CHEMICAL DEAFFERENTATION



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Abstract

Morphological features of the neurons containing neurofilaments with molecular mass of 200 kD (NF200+), were studied in the sensory ganglia of thoracic and lumbar spinal nerves in rats (n=80) during the first year of their life. Capsaicin treatment (150 mg/kg) of the newborn animals resulted in the change of age dynamics of NF200+ neurons. This was reflected by a reduction of NF200+ neuron numbers and their cross-sectional areas in both ganglia. Segmental differences included greater reduction of NF200+ neuron number in the sensory ganglion of lumbar spinal nerve in both early and late developmental periods.

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