Email this article THE ORGANIZATION OF THE PROJECTIONS OF THE ROSTROMEDIAL TEGMENTAL NUCLEUS TO THE STRIATUM IN CANINE BRAIN
- Authors: Gorbachevskaya A.I.1
-
Affiliations:
- RAS I. P. Pavlov Institute of Physiology
- Issue: Vol 143, No 3 (2013)
- Pages: 022-026
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398613
- DOI: https://doi.org/10.17816/morph.398613
- ID: 398613
Cite item
Open Access
Access granted
Abstract
Method of retrograde axonal transport of horseradish peroxidase and fluorochromes was used to study the organization of the projections of the rostromedial tegmental nucleus (RMTN) to the functionally diverse regions of striatal structures of dog brain (n=26). It was found that the projection fibers of the neurons of RMTN limbic medial part were directed only to the ventral limbic segments of the nucleus caudatus, the putamen and the nucleus accumbens. However, the convergence of the projection fibers originating from the neurons of functionally different RMTN parts was observed in the majority of the segments of the striatal structures. Thus, the projection fibers of the motor lateral and the limbic medial RMTN parts were directed to the motor dorso-lateral segment of the caudate nucleus and also to the striatal segments, which were innervated by the fibers from the neurons of functionally diverse structures (ventro-lateral segment of the caudate nucleus and the lateral segment of the nucleus accumbens). Possible pathways conducting functionally different information and its integration in the investigated projection systems are discussed.
Full Text
About the authors
A. I. Gorbachevskaya
RAS I. P. Pavlov Institute of Physiology
Email: aig@infran.ru
References
- Горбачевская А. И. и Чивилёва О. Г. Морфологический анализ путей проведения информации в базальных ганглиях млекопитающих. Успехи физиол. наук, 2003, т. 34, № 2, с. 46–63.
- Bourdy R. and Barrot M. A new control center for dopaminergic systems: pulling the VTA by the tail. Trends Neurosci., 2012, v. 35, № 11, p. 681–690.
- DeLong M. R. and Wichmann T. Circuits and Circuit Disorders of Basal Ganglia. Neurol. Rev., 2007, v. 64, № 1, p. 20–24.
- Dua-Sharma S., Sharma K. N. and Jacobs H. L. The canine brain in stereotaxic coordinates. Cambridge, Massachusetts and London, the MIT Press, 1970.
- Haber S. N. Functional anatomy and physiology of the basal ganglia: non-motor functions. In: Current clinical Neurology: deep brain stimulation in neurological and psychiatric disorders. Totowa, N. J., Humana Press, 2008, p. 33–62.
- Holstege G. The mesopontine rostromedial tegmental nucleus and the emotional motor system: role in basic survival behavior. J. Comp. Neurol., 2009, v. 513, № 6, p. 559–565.
- Jhou T. C., Fields H. L., Baxter M. G. et al. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron, 2009, v. 61, № 3, p. 786–800.
- Jhou T. C., Geisler S., Marinelli M. and Degarmo B. A. The mesopontine rostromedial tegmental nucleus: a structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. J. Comp. Neurol., 2009, v. 513, № 6, p. 566–596.
- Kaufling J., Vienante P., Pawlowski S. A. and Freund-Mercier M.-J. Afferents to the GABAergic tail of the ventral tegmental area in the rat. J. Comp. Neurol., 2009, v. 513, № 6, p. 597–621.
- Kuypers H. G.J. M., Catsman-Berrevoets C. E. and Padt R. E. Retrograde axonal transport of fluorescent substances in the rat`s forebrain. Neurosci. Lett., 1977, v. 6, № 3, p. 127–135.
- Lavezzi H. N., Parsley K. P. and Zahm D. S. Mesopontine rostromedial tegmental nucleus neurons projecting to the dorsal raphe and pedunculopontine tegmental nucleus: psychostimulantelicited Fos expression and collateralization. Brain Struct. Funct., 2012, v. 217, № 3, p. 719–734.
- Lavezzi H. N. and Zahm D. S. The mesopontine rostromedial tegmental nucleus: An integrative modulator of the reward system. Basal ganglia, 2011, v. 1, № 4, p. 191–200.
- Mesulam M. M. Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J. Histochem. Cytochem., 1978, v. 26, № 2, p. 106–117.
- Wichman T. and DeLong M. R. Deep-brain stimulation for basal ganglia disorders. Basal ganglia, 2011, v. 1, № 2, p. 65–77.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).