APPLICATION OF THE IMMUNOHISTOCHEMICAL DETECTION OF PGP 9.5 PROTEIN FOR THE STUDY OF RAT AND HUMAN HEART INNERVATION



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Abstract

In this paper we describe the modern immunohistochemical method detecting the neuronal marker PGP 9.5. The application of this method for the study of the innervation of rat and human heart, the detailed examination of the topography of the cardiac nervous apparatus, as well as their changes in pathological states, is demonstrated. Structural organization and the nature of the terminal branches of nerve apparatus suggest that they have afferent function. Protocol of the reaction demonstrating PGP 9.5 on paraffin sections is presented.

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About the authors

D. E. Korzevskiy

RAMS North-Western Branch Institute of Experimental Medicine

Email: iemmorphol@yandex.ru

Ye. G. Sukhorukova

RAMS North-Western Branch Institute of Experimental Medicine

Ye. S. Petrova

RAMS North-Western Branch Institute of Experimental Medicine

A. F. Tzukanova

Bureau of Forensic Medicine

Ye. I. Chumasov

RAMS North-Western Branch Institute of Experimental Medicine

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