CHANGES OF Y NEURON FORMATION IN CAT VISUAL SYSTEM DURING EARLY POSTNATAL ONTOGENESIS UNDER THE INFLUENCE OF BINOCULAR RHYTHMIC LIGHT STIMULATION



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Abstract

To examine the effect of an artificial rhythmic light stimulation on the development of structural and functional organization of Y neurons of cat visual system in the ontogenesis, the distribution of the neurons immunopositive to SMI-32 antibodies was studied in lateral geniculate nucleus (LGN) and posteromedial suprasylvian area (PMLS). Laminar distribution of SMI-32-positive neurons and neuronal body profile area were analyzed in intact animals (n=4) and in kittens (n=4) grown under conditions of rhythmic light stimulation with15 Hz frequency for 4 months. In light-stimulated animals, changes in laminar distribution of immunopositive neurons were detected in both LGN (decline in the percentage of the immunopositive cells in C M layer) and in PMLS area (decrease in cell count in layer V). Morphometric analysis has shown the significant reduction of cell body profile area in immunopositive neurons in light-stimulated kittens only in layers III and V of PMLS area. The data obtained suggest that Y channel functional disturbances in light-stimulated animals are caused by the structural and metabolic changes detected in Y neurons.

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About the authors

N. S. Merkuliyeva

RAS I. P.Pavlov Institute of Physiology

Email: mer-natalia@yandex.ru

A. A. Mikhalkin

RAS I. P.Pavlov Institute of Physiology

Email: michalkin@mail.ru

N. I. Nikitina

RAS I. P.Pavlov Institute of Physiology

D. A Nefyodov

RAS I. P.Pavlov Institute of Physiology

Email: den-nefedov86@rambler.ru

F. N. Makarov

RAS I. P.Pavlov Institute of Physiology

Email: felixmakarov@mail.ru

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