STRUCTURAL AND QUANTITATIVE CHARACTERISTICS OF THE AMYGDALA AND PRIMARY SOMATOSENSORY CORTEX OF ALCOHOL-PREFERRING AND ALCOHOL NON-PREFERRING RATS
- Authors: Akhmadeyev A.V.1, Fyodorova A.M.1, Kalimullina L.B.1
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Affiliations:
- Bashkir State University
- Issue: Vol 145, No 1 (2014)
- Pages: 19-23
- Section: Articles
- Submitted: 09.05.2023
- Published: 15.02.2014
- URL: https://j-morphology.com/1026-3543/article/view/398718
- DOI: https://doi.org/10.17816/morph.398718
- ID: 398718
Cite item
Abstract
The aim of the study was the structural and planimetric characteristics of the nuclei and intermediate formations of corticomedial and basolateral groups of structures of the amygdala and the primary somatosensory cortex in 10 alcohol-preferring (AP) and 10 alcohol non-preferring (ANP) rats, as well as demonstration of the ifferences in concentration of dopamine and its metabolite — 3,4 dihydroxyphenylacetic acid (DOPAK) in the amygdala. Measurements of absolute and specific areas of the structures studied were conducted on the cytoarchitectonic slides stained using Nissl cresyl violet method. No differences in the specific area of corticomedial and basolateral amygdala groups of structures were detected between two groups of rats studied. In ANP rats higher specific areas of the primary somatosensory cortex and of the amygdala in the left hemisphere were found, predetermined by the larger sizes of basolateral group. Analysis of DOPAK concentration in the amygdala revealed it in nearly equal quantities in AP and ANP rats, while, concentration of dopamine was significantly greater in AP rats. DOPAK/dopamine ratio was twice greater in AP rats which is indicative of dopamine accelerated metabolism.
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About the authors
A. V. Akhmadeyev
Bashkir State University
Email: mpha@ufanet.ru
Department of Human and Animal Morphology and Physiology
A. M. Fyodorova
Bashkir State University
Email: marmishka-06@mail.ru
Department of Human and Animal Morphology and Physiology
L. B. Kalimullina
Bashkir State UniversityDepartment of Human and Animal Morphology and Physiology
References
- Акмаев И. Г. и Калимуллина Л. Б. Миндалевидный комплекс мозга: функциональная морфология и нейроэндокринология. М., Наука, 1993.
- Ахмадеев А. В. Экспериментальные подходы к исследованию роли генотипа по локусу Taq 1A дофаминового Д2 рецептора в наркотической зависимости. Рос. физиол. журн. им. И. М. Сеченова, 2010, т. 96, № 5, с. 513–520.
- Ахмадеев А. В. и Калимуллина Л. Б. Древняя амигдала: цитоархитектоника, организация и цитологические характеристики нейронов. Морфология, 2004, т. 126, вып. 5, с. 15–19.
- Ахмадеев А. В. и Калимуллина Л. Б. Исследование факторов предрасположенности к алкоголизму: сравнительный анализ поведенческих реакций и системы биогенных аминов у предпочитающих и не предпочитающих алкоголь крыс. Успехи соврем. естествознания, 2013, № 1, c. 15–20.
- Борисова Е. В., Русаков Д. Ю. и Судаков С. К. Различия характеристик опиатных и катехоламинергических рецепторов стриатума и коры головного мозга крыс линий Fischer-344 и Wag/Gsto могут обуславливать различия в положительно-подкрепляющем действии морфина. Бюл. экспер. биол., 1992, № 9, с. 296–298.
- Ещенко Н. Д. Биохимия психических и нервных заболеваний. СПб., Издательский дом Санкт-Петербургск. ун-та, 2004.
- Меркулов Г. А. Курс патогистологической техники. Л., Медицина, 1969.
- Патент РФ № 2438193. Способ приготовления переживающих срезов пириформной доли мозга. А. В. Ахмадеев иЛ. Б. Калимуллина. Заявка № 2007149137 от 25.12.2007 г. БИ, 2011, № 36, с. 215–220.
- Bertolino A., Fazio L., Caforio G. et al. Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia. Brain, 2009, v. 132, № 2, p. 417–425.
- Goncalves-Pereira P. M., Oliveira E. and Insausti R. Quantitative volumetric analysis of the hippocampus, amygdala and entorhinal cortex: normative database for the adult Portuguese population. Rev. Neurol., 2006, v. 42, № 12, p. 713–722.
- Jocham G., Klein T.A., Neumann J. et al. Dopamine DRD2 polymorphism alters reversal learning and associated neural activity. J. Neurosci., 2009, v. 29, № 12, p. 3695–3704.
- Makris N., Gasic G. P., Seidman L. J. et al. Decreased absolute amygdala volume in cocaine addicts. Neuron, 2004, v. 44, № 4, p. 729–740.
- Oliveira A. R., Reimer A. E., de Macedo C. E. et al. Conditioned fear is modulated by D2 receptor pathway connecting the ventral tegmental area and basolateral amygdala. Neurobiol. Learn Mem., 2011, v. 95, № 1, p. 37–45.
- Paxinos G. and Watson C. The rat brain in stereotaxic coordinates. Sydney, Academic., 1998.
- Pinard C. R., Muller J. F., Mascagni F. and McDonald A. J. Dopaminergic innervation of interneurons in the rat basolateral amygdala. Neuroscience, 2008, v. 157, № 4, p. 850–863.
- Usiello A., Baik J. H., Roug-Pont F. et al. Distinct functions of the two isoforms of dopamine D2 receptors. Nature, 2000, v. 408, № 6809, p. 199–203.
- Yang R. J., Mozhui K., Karlsson R. M. et al. Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning. Neuropsychopharmacology, 2008, v. 33, № 11, p. 2595–2604.
- Zhang Y., Bertolino A., Fazio L. et al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. J. List Proc. Natl. Acad. Sci. USA, 2007, v. 104, № 51, p. 349–378.