Email this article INTERRELATIONS OF PINEAL GLAND MORPHO-FUNCTIONAL INDICES AND IMMUNE SYSTEM ORGANS IN RATS EXPOSED TO NATURAL ILLUMINATION REGIME AND CONTINUOUS ILLUMINATION
- Authors: Litvinenko G.I.1, Shurlygina A.V.1, Gritsyk O.B.2, Mel’nikova Y.V.1, Avrorov P.A1, Tenditnik M.V.2, Trufakin V.A1
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Affiliations:
- RAMS Siberian Branch Scientific Research Institute of Physiology and Fundamental Medicine
- RAMS Siberian Branch Scientific Research Institute of Clinical and Experimental Lymphology
- Issue: Vol 145, No 2 (2014)
- Pages: 26-30
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398746
- DOI: https://doi.org/10.17816/morph.398746
- ID: 398746
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Abstract
The objective of this investigation was to determine the complex response of the pineal gland (PG) and of the organs of the immune system in Wistar rats in response to a violation of the illumination regime in the experiment. Animals were kept under natural light regime and continuous illumination for 14 days. After that rats were sacrificed and the mass of the body, PG, gonads, thymus and spleen was measured. Thymus and spleen cell subpopulations were determined by flow cytometry. The lipofuscin content in PG was determined by measuring an auto-fluorescence intensity in frozen tissue sections in the wavelength range of 505-545 nm using a confocal laser scanning microscope LSM 510 META (Carl Zeiss). The correlation analysis showed an increase in the amount and the change of sign and direction of relations between the indices of the state of PG and the immune system. This indicates the up-regulation of the intensity of intersystem relationships and the change of migration and differentiation vector of immunocompetent cells.
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About the authors
G. I. Litvinenko
RAMS Siberian Branch Scientific Research Institute of Physiology and Fundamental Medicine
A. V. Shurlygina
RAMS Siberian Branch Scientific Research Institute of Physiology and Fundamental Medicine
Email: anna_v_s@mail.ru
O. B. Gritsyk
RAMS Siberian Branch Scientific Research Institute of Clinical and Experimental Lymphology
Ye. V. Mel’nikova
RAMS Siberian Branch Scientific Research Institute of Physiology and Fundamental Medicine
P. A Avrorov
RAMS Siberian Branch Scientific Research Institute of Physiology and Fundamental Medicine
M. V. Tenditnik
RAMS Siberian Branch Scientific Research Institute of Clinical and Experimental Lymphology
V. A Trufakin
RAMS Siberian Branch Scientific Research Institute of Physiology and Fundamental Medicine
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).