Email this article NESTIN EXPRESSION IN EPENDYMAL CELLS OF LATERAL VENTRICLES OF THE RAT BRAIN IN AGING
- Authors: Korzhevskiy D.E.1, Kirik O.V.1, Alekseyeva O.S.1,2
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Affiliations:
- RAS Institute of Experimental Medicine
- RAS I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry
- Issue: Vol 146, No 5 (2014)
- Pages: 70-72
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398797
- DOI: https://doi.org/10.17816/morph.398797
- ID: 398797
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Abstract
It is known that during development of the brain, with the progress of ependendymocyte differentiation from radial gliocytes, the synthesis of nestin is stopped. However, it was shown that in the ependyma of the lateral brain ventricles nestin synthesis was resumed in response to ischemic injury. The aim of the present study was to test the hypothesis of possible re-expression of nestin in the ependyma in aging. The study was performed on male Wistar rats aged 4 (n=4) and 28 months (n=3). In older animals the expression of nestin was demonstrated in the ependyma of the lateral ventricles of the brain. It was also found that the area of the medial and upper walls of the lateral ventricle contained the regions of ependyma, in which all cells had intense cytoplasmic staining. The causes of the phenomenon described remain unclear.
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About the authors
D. E. Korzhevskiy
RAS Institute of Experimental Medicine
Email: dek2@yandex.ru
O. V. Kirik
RAS Institute of Experimental Medicine
Email: olga_kirik@mail.ru
O. S. Alekseyeva
RAS Institute of Experimental Medicine; RAS I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).