REGULATION OF HAIR FOLLICLE CYCLE



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Abstract

This review is devoted to the control of hair growth. The hair follicle undergoes cyclic transformation from the resting phase (telogen) to the growth phase (anagen). The latter phase is characterized by rapid proliferation of follicular keratinocytes and elongation and thickening of the hair shaft. The regression phase (catagen) leads to the involution of the hair follicle. These cyclic changes include rapid remodeling of both the epithelial and the dermal components. They are controlled by numerous different factors: sex hormones, neurotrophins, FGF, TGF, BMP, VEGF, Sonic Hedgehog, and other signaling pathways.

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About the authors

V. L. Goryachkina

I. M. Sechenov First Moscow State Medical University

M. Yu. Ivanova

I. M. Sechenov First Moscow State Medical University

Email: ivanova_m_y@mail.ru

D. A. Tsomartova

I. M. Sechenov First Moscow State Medical University

Email: dtsomartova@mail.ru

N. L. Kartashkina

I. M. Sechenov First Moscow State Medical University

Email: knlmma@mail.ru

S. L. Kuznetsov

I. M. Sechenov First Moscow State Medical University

Email: vakmedbiol@rambler.ru

References

  1. Андреев С. И. Тайна роста и потери волос: центральная роль стволовых клеток. Косметика и медицина, 2003, № 3, c. 16-22.
  2. Ноздрин В. И. и Горпинич И. В. Смена волос. В кн.: Ретиноиды. М., изд. ЗАО «Ретиноиды», 2007, т. 27, с. 35-53.
  3. Харитонова Е. Е. и Цисанова Н. И. Гормональная регуляция роста волос. Экспер. и клин. дерматокосметол., 2009, № 3, c. 40-41.
  4. Bayer-Garner J., Sanderson R. and Smoller B. Syndican-1 is strongly expressed in the anagen hair follicle outer root sheath and in the dermal papilla but expression diminishes with involution of the hair follicle. Am. J. Dermatopathol., 2002, v. 24, № 6, p. 484-489.
  5. Bernand B. A. The human hair follicle, a bistable organ. Exp. Dermatol., 2012, v. 21, p. 401-403.
  6. Botchkarev V.A., Botchkareva N. V., Albers K. M. et al. Neutotrophin-3 involvement in the regulation of hair follicle morphogenesis. J. Invest. Dermatol., 1998, v. 111, p. 279-285.
  7. Botchkarev V.A., Botchkareva N. V., Welker P. et al. A new role of neurotrophins: involvement of brain - derived neurotrophicfactor and neurotrophin-4 in hair cycle control. FASEB J., 1999, v. 13, p. 395-410.
  8. Botchkarev V. and Kishimoto Y. Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. J. Invest. Dermatol., 2003, v. 120, № 1, p. 36-47.
  9. Botchkarev V. and Paus R. Molecular biology of hair morphogenesis: Development and cycling. J. Exp. Zool., 2003, v. 298, № 1, p. 164-180.
  10. Botchkarev V.A., Welker P., Albersk M. et al. A new role of neu ro trophin-3: involvement in the regulation of hair follicle regression (catagen). Am. J. Pathol., 1998, v. 153, p. 785-799.
  11. Botchkareva N. V., Ahluwalia G. and Shander D. Apoptosis in the hair follicle. J. Invest. Dermatol., 2006, v. 126, p. 258-264.
  12. Botchkareva N. V., Botchkarev V. A., Welker P. et al. New roles of glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am. J. Pathol,. 2000, v. 156, p. 1041-1053.
  13. Botchkareva N. V., Khlgation M. and Longley B. SCF/ckit signaling is reguired for cycle regeneration of the hair pigmentation unit. FASEB J., 2001, v. 15, p. 645-658.
  14. Chase H. B. Growth of hair. Physiol. Rev., 1954, v. 34, p. 113- 126.
  15. Cotsarelis G. and Millar S. E. Towards a molecular understanding of hair loss and its treatment. Trends Mol. Med., 2001, v. 7, № 7, p. 293-301.
  16. Couchman J. Hair follicle proteoglycans. J. Invest. Dermatol., 1993, v. 101 (1 suppl.), p. 60-64.
  17. Dawber R. and Van Neste D. Hair and scalp disorders: common presenting signs, differential diagnosis and treatment. London, Philadelphia, J. B. Lippincott Company, 1995.
  18. Dry F. W. The coat of the mouse (Mus musculus). J. Genet., 1926, v. 16, p. 287-340.
  19. Foitzik K., Krause K. Conrad F et al. Human scalp hair follicles are both a target and a source of prolactin, wich serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. Am. J. Pathol., 2006, v. 168, p. 748-756.
  20. Foitzik K., Lindner G., Mueller-Roever S. et al. Control of murine hair follicle regression (catagen) by TGF-β in vivo. FASEB J., 2000, v. 14, p. 752-760.
  21. Geyfman M. and Anderson B. How the skin can tell time. J. Invest. Dermatol., 2009, v. 129, p. 1063-1066.
  22. Geyfman M. and Andersen B. Clock genes, hair growth and aging. Aging, 2010, v. 2, № 3, p. 122-128.
  23. Havlikova B., Biro T., Mescalchin A. et al. A human folliculoid microspera assay for exploring epithelial-mesenchymal interactions in the human hair follicle. J. Invest. Dermatol., 2009, v. 129, № 4, p. 972-983.
  24. Hebert J. M., Rosenquist T., Gotz J. and Martin G. R. FGF 5 as a regulator of the hair growth cycle. Cell, 1994, v. 78, p. 1017-1025.
  25. Hibino T. and Nishiyama T. Role of TGF-β2 in the human hair cycle. J. Dermatol. Sci., 2004, v. 35, p. 9-18.
  26. Hunt T. and Sassone-Corsi P. Riding tandem: circadian clocks and the cell cycle. Cell, 2007, v. 129, p. 461-464.
  27. Inui S. and Itami S. Androgens actions on the human hair follicle: perspective. Exp. Dermatol., 2013, v. 22, p. 168-171.
  28. Jones L. N., Peet D. J., Danks D. M. et al. Hairs from patients with Maple Syrup Urine Disease show a structural defect in the fiber cuticle. J. Invest. Dermatol., 1996, v. 106, p. 461-464.
  29. Kanq J. I., Kim E. J., Kim M. K. et al. The promoting effect of Ichige sinicola on hair growth. Mar. Drugs, 2013, v. 11, p. 1783- 1799.
  30. Lutz G. Effects of cyclosporine A on hair. Skin Pharmacol., 1994, v. 7, p. 101-104.
  31. Maurer M., Fischer E., Handjiski B. et al. Activated skin mast cells are involved in murine hair follicle regression (catagen). Lab. Invest., 1997, v. 77, p. 319-332.
  32. Mecklenburg L., Tobin D. J., Muller-Rover S. et al. Active hair growth (anagen) is associated with angiogenesis. J. Invest. Dermatol., 2000, v. 114, p. 909-916.
  33. Milner Y., Sudnik Y., Fillipi M. et al. Exogen, shedding phase of the hair growth cycle: characterization of mouse model. J. Invest. Dermatol., 2002, v. 119, p. 639-644.
  34. Muller-Rover S. and Botchkarev V.A. Chronobiology of the hair follicle: hunting the «hair cycle clock». J. Invest. Dermatol., 1999, v. 4, p. 338-345.
  35. Muller-Rover S., Bulfone-Paus S., Welker P. et al. ICAM-1 and hair follicle regression. J. Histochem. Cytochem., 2000, v. 48, p. 557-568.
  36. Nakatake Y., Hoshikawa M., Asaki T. et al. Identification of novel fibroblast growth factor FGF 22, preferentially expressed in the inner root sheath of hair follicle. Biochem. Biophys. Acta, 2001, v. 1517, № 3, p. 460-463.
  37. Nelson W. J. and Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Sience, 2004, v. 303, p. 1483-1487.
  38. Oro A. E. and Higgin K. M. Hair cycle regulation on Hedgehog signal reception. Dev. Biol., 2003, v. 255, p. 238-248.
  39. Panteleyev A., Jahoda C. and Christiano A. Hair follicle predetermination. J. Cell Sci., 2011, v. 114, p. 3419-3431.
  40. Paus R., Maurer M., Slominskik A.et al. Mast cell involvement in murine hair growth. Dev. Biol., 1994, v. 163, p. 230-240.
  41. Paus R., Van Der Veen C., Eichmuller S. et al. Generation and cyclic remodeling of the hair follicle immune system in mice. J. Invest. Dermatol., 1999, v. 111, p. 7-18.
  42. Peters E. M., Hansen M. G., Overall R. W. et al. Control of human hair growth by neurotrophins: brain-derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor beta 2 expression. J. Invest. Dermatol., 2005, v. 124, № 4, p. 675-685.
  43. Peters E. M., Hendrix S., Golz G. et al. Nerve growth factor and its precursor differentially regulate hair cycle progression in mice. J. Histochem. Cytochem., 2006, v. 54, № 3, p. 275-288.
  44. Plikus M. V., Mayer J. A., de la Cruz D. et al. Cyclic dermal BMP signaling regulates stem cell activation during hair regeneration. Nature, 2008, v. 451, № 17, p. 340-345.
  45. Quarcoo D., Fisher T. C., Peckenschneider N. et al. High abundances of neurotrophin 3 in atopic dermatitis mast cell. J. Occup. Med. Toxicol., 2009, v. 4, № 8, p. 1-7.
  46. Randall V.A. and Botchkareva N. V. Biology of hair growth. In: Cosmetic applications of laser and light-based systems. Norwich, NY, William Andrew Inc., 2009, p. 3-35.
  47. Sato N., Leopold P. L. and Crystal R. G. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog. J. Clin. Invest., 1999, v. 104, p. 855-864.
  48. Schneider M. R., Schmidt-Ullrich R. and Paus R. The hair follicle as a dynamic miniorgan. Curr. Biol., 2009, v. 19, p. 132-142.
  49. Spradling A., Drummond-Barbosa D. and Kai T. Stem cells find their niche. Nature, 2001, v. 414, p. 98-104.
  50. Stenn K. S., Parimoo S. and Prouty S. M. Growth of the hair follicle: a cycling and regenerating biological system. In: Molecular Basis of Epithelial Appendage Morphogenesis, Austin, Texas, R. G. Landes comp., 1998, p. 111-130.
  51. Stenn K. S. and Paus R. What controls hair follicle cycling? Exp. Dermatol., 1999, v. 8, p. 229-236.
  52. Stenn K. S. and Paus R. Control of hair follicle cycling. Physiol. Rev., 2001, v. 81, p. 449-494.
  53. Suzuki S., Ota K. and Ymamura T. Dual-mode regulation of hair growth cycle by two FGF-5 gene products. J. Invest. Dermatol., 2000, v. 114, p. 456-463.
  54. Tobin D. J. Hair in Toxicology. Part I. In: The Biogenesis and Growth of Human Hair. Alton, IL, The Book Place, 2005, p. 1-33.
  55. Telek A., Biro T., Bodo E. et al. Inhibition of human hair follicle growth by endo- and exocannabinoids. FASEB J., 2007, v. 21, p. 3534-3541.
  56. Viallet J. P. and Dhouailly D. Retinoic acid and mouse skin morphogenesis. I. Expression pattern of retinoic acid receptor genes during hair vibrissa follicle, plantar, and nasal gland development. J. Invest. Dermatol., 1994, v. 103, № 1, p. 116-121.
  57. Weger N. and Schlake T. IGF-I signaling controls the hair growth cycle and the differentiation of hair shafts. J. Invest. Dermatol., 2005, v. 125, № 5, p. 873-882.
  58. Yano K., Brown L. F. and Detmar M. Control of hair growth and follicle size by VEGF- mediated angigenesis. J. Clin. Invest., 2001, v. 107, p. 409-417.
  59. Yano K., Brown L. F., Lawler Y. et al. Thrombospondin-1 plays a critical role in the induction of hair follicle involution and vascular repression during catagen phase. J. Invest. Dermatol., 2003, v. 120, p. 14-19.
  60. Zimber M. P., Ziering C., Zeigler F. et al. Hair regrowth following a Wnt- and follistatin containing treatment: safety and efficacy in a first-in-man phase 1 clinical trial. J Drugs Dermatol., 2011,v. 10, № 11, p. 1308-1312.

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