MORPHO-FUNCTIONAL COMPENSATORY CHANGES OF COLONIC MUCOSA AFTER LONG-TERM EXPOSURE TO URINE IN THE EXPERIMENT



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Abstract

Using 60 outbred albino male rats, the changes of colonic mucosa were studied after rectal infusion of urine for 1, 3 and 5 months. In response to prolonged exposure to urine, the mucosa was found to undergo gradual atrophic changes, including the reduction of its thickness and crypt depth. Moreover, the number of goblet cells was significantly decreased. Oral correction by weak solution of sodium hydrocarbonate could slow down the progression of atrophicprocesses in colonic mucosa.

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References

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