JUXTAORAL ORGAN OF CHIEVITZ



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Abstract

This review presents the analysis of the systematized data on human juxtaoral organ (JOO) development, structure and function
based on the results of classical and recent morphological
studies. JOO morphogenesis is traced, including the appearance
of its anlage at the bottom of the primitive mouth, epithelial
invagination into the mesenchyme, JOO detachment from the oral epithelium, its innervation, connective tissue capsule formation, and final maturation. The analysis of the results of macroscopical, histological, electron microscopical, histochemical
and immunohistochemical studies is presented, suggesting high
metabolic and synthetic activity of its epithelium, which expresses
several neural markers, and emphasizing a rich innervation
of both its epithelial and stromal components. The findings
supporting the concepts of JOO secretory and mechanosensory
functions, are examined. The data on the differential diagnosis
between JOO and tumoral processes are discussed, as well as the pathological changes of JOO it self and their significance for the diagnosis of the diseases.

About the authors

V L Bykov

V L Bykov

I.P. Pavlov St. Petersburg State Medical University

I.P. Pavlov St. Petersburg State Medical University

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