PATHOLOGIC CHANGES OF NEURONS OF MESOCORTICOLIMBIC DOPAMINERGIC SYSTEM IN HEALTHY HUMANS AND RATS



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Abstract

The purpose of the present study was to demonstrate pathologically changed forms of neurons and intensity of the neuronoglial interactions which represented the normal standard for the interconnected parts of mesocorticolimbic dopaminergic system (MDS) in 6 intact adult female Wistar rats and in 5 healthy humans aged 24-45 years. The percentages of unchanged, hypochromic, pyknomorphic and ghost neurons in proportion to their total number were determined in the anteromedial part of paranigral nucleus of ventral tegmental region of midbrain tegmentum (TVR), compact part of black substance (BS), anteromedial part of accumbent nucleus (NA) close to anterior brain commissure and in middle of layer III of a pregenual part of field 24b (Cg3 in rats). The structures of the brain, unrelated to MDS - layers III and V of field 1 - were investigated as the control. The data obtained indicate significant changes of MDS neurons in the healthy people as compared to those in the intact rats. The number of pathologically changed MDS neurons, as well as the number of fibers in medial forebrain bundle, were shown to decrease with the increase of distance from catecholaminergic nuclei of reticular formation, reaching the minimum in non-dopaminoceptive and low-noradrenoceptive layer V of field 1. More than 25% of the neurons in TVR paranigral nucleus were ghost cells. Over 30% of NA neurons were hypochromic and ghost cells. About 25% of neurons in field 24b were ghost cells, hypochromic and pyknomorphic. The intensity of neuronoglial interaction in human and rat dopaminergic nuclei is significantly greater than in the projectional parts of MDS and in the layers of field 1, unrelated to it. Local changes of MDS neurons in man and high intensity of neuronoglial interactions in dopaminergic nuclei reflect the blurring of the boundaries between the normal state and pathology and lower durability of this system, as compared to that of the cortical fields remote from the source of catecholaminergic fibers.

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A V Droblenkov

A V Droblenkov

References

  1. Анохина И.П., Арзуманов Ю.Л., Веретинская А.Г. и др. Диагностика генетической предрасположенности к зависимости от психоактивных веществ. В кн.: Проблемы диагностики и лечения алкоголизма и наркоманий. М., Анахарсис, 2001, с. 6-29.
  2. Афанасьев В.В., Рубитель Л.Т. и Афанасьев А.В. Острая интоксикация этиловым алкоголем. СПб., Интермедика, 2002.
  3. Востриков В.М. Олигодендроглия в мозге человека при шизофрении и аффективных расстройствах: Автореф. дис. … д-ра мед. наук. М., 2008.
  4. Должанский О.В. Судебно-медицинская оценка морфологических изменений головного мозга при хронических опийных наркоманиях: Автореф. дис. … канд. мед. наук. М., 2001.
  5. Дробленков А.В. и Карелина Н.Р. Структурные особенности нейронов и макроглиоцитов взаимосвязанных отделов мезоаккумбоцингулярной дофаминергической системы крыс. Морфология, 2009, т. 136, вып.5 , с. 11-17.
  6. Жаботинский Ю.М. Нормальная и патологическая морфология нейрона. М., Наука, 1965.
  7. Лакин Г.Ф. Биометрия. Учебное пособие для биологических специальностей вузов. М., Высш. школа, 1980.
  8. Нуманд Л.Б. и Оттер М.Я. Реакция организма на действие барбитуратов и активность моноаминергических процессов в мозге. Фармакол. и токсикол., 1983, № 3, с. 23-25.
  9. Певзнер Л.З. Функциональная биохимия нейроглии. Л., Наука, 1972.
  10. Писарев В.Б., Баннов А.Н. и Должанский О.В. Морфофункциональная характеристика срединного центра таламуса крыс в условиях эмоционального стресса. В кн.: Морфология компенсаторных и приспособительных процессов при различных приспособительных состояниях. Волгоград, изд. Волгоградск. мед. акад., 1998, т. 54, вып. 2, с. 97-122.
  11. Уранова Н.А. Дофаминергическая система мозга при шизофрении (ультраструктурно-морфометрическое исследование): Автореф. дис. … д-ра мед. наук. М., 1995.
  12. Chrousos G.P. and Gold P.W. The concepts of stress system disorders: overview of behavioral and physical homeostasis. J. Am. Med. Inform. Assoc., 1992, v. 267, p. 1244-1252.
  13. Bjorklund A. amd Lindvall O. Dopamine-containing systems in the CNS. In: Handbook of Neuroanatomy. V. 2. Classical neurotransmitters in the CNS. Part 1. Amsterdam, New York, Oxford, Elsevier Science Publishers, 1984, р. 55-122.
  14. Brown R.M., Crane A.M. and Goldman P.S. Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates. Brain Res., 1979, v. 168, p. 133-150.
  15. Dai X., Lercher L.D., Clinton P.M. et al. The trophic role of oligodendrocytes in the basal forebrain. J. Neurosci., 2003, v. 23, № 13, p. 5846-5853.
  16. George S. R., Fan T., Ng G. Y. et al. Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine. J. Pharmacol. Exp. Therapy, 1995, v. 273, p. 373-379.
  17. Hassler R. Zur Normalenanatomie der Substantia nigra. J. Psychol. Neurol., 1937, Bd. 48, H. 1-2, S. 1-55.
  18. Hyden H. Behavior, neural function and RNA. Prog. Nucleic Acid Res. Mol. Biol., 1967, v. 6, p. 187-218.
  19. Koob G.F. Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol., Sci., 1992, v. 13, № 5, p. 177-180.
  20. Le Moal M. and Simon H. Mesocorticolimbic dopamine network: functional and regulatory roles. Physiol. Rev., 1991, v. 71, p. 155-234.
  21. McBride W.J., Murphy J.M., Lumeng L. and Li T.K. Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol, 1990, v. 7, № 3, p. 199-205.
  22. Oads R.S. and Halliday G.M. Ventral tegmental system: neurobiology. I. Anatomy and connectivity. Brain Res. Rev., 1987, v. 12, р. 117-165.
  23. Richards J.G. Ultrastructural effects of 6-hydroxydopamine on catecholamine containing neurons in the rat brain. In: 6-hydroxydopamine and catecholamine neurons. Amsterdam, North-Holland Publ., 1971, p. 151-161.
  24. Rossetti Z. L., Hmaidan Y. and Gessa G. L. Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. Eur. J. Pharmacol., 1992, v. 221, № 2-3, p. 227-234.
  25. Shabanov P.D., Lebedev A.A., Droblenkov A.V. and Lubimov A.V. Delayed behavioral and morphological subsequences of activation of the stress-antistress system in early ontogeny in rats. Int.J. Neuropsychopharmacol., 2008, v. 11, suppl. 1, р. 208.
  26. Steward O. Functional Neuroscience. New-York, Springer, 2000.
  27. Wise R.A. and Rompre P.P. Brain dopamine and reward. Ann. Rev. Psychol., 1989, v. 40, p. 191-225.

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