AGE CHANGES OF THE CONNECTIVE TISSUE STRUCTURES OF HUMAN PENIS



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Abstract

This investigation was aimed at the study of age changes of penis connective tissue structures. Tissue fragments of penis were obtained from 20 cadavers of men at the age of 20-38 years in group I, and from 20 cadavers of men at the age of 41-59 years in group II. The criteria for the exclusion of material from the research were arterial hypertension, diabetes mellitus, atherosclerosis of internal iliac arteries, Peyronie's disease, and anomalies of genital organ development. It was shown that in the cavernous body of penis, aging was associated with the increased amount and thickening of collagen and argyrophilic fibers, decreased content and thinning of elastic fibers, and the reduced amount of smooth muscle cells (SMC). The average area of fibroblast and SMC nucleolus was not different in both groups studied. The average area of endotheliocyte nucleolus was equal to 1.9±0.9 μm2 in group II, being lower than that one in group I, in which this index was equal to 2.1±0.9 μm2. No differences in the content of type III and IV collagen were found between the study groups. Age-associated decrease in the average area of endothelial cell nucleolus in the cavernous bodies may reflect the reduction of the activity of these cells and may indicate the development of endothelial dysfunction, which is one of the most important steps in the morphogenesis of age-related male erectile dysfunction.

References

  1. Бобров И.П., Авдалян А.М., Черданцева Т.М. и др. Модифицированный метод выявления аргирофильных белков области ядрышкового организатора на парафиновых срезах. Морфология, 2010, т. 138, вып. 5, с. 65-68.
  2. Калантаевский К.А. Морфология и физиология кожи человека. Киев, Здоров'я, 1965.
  3. Криворучко А.Ю. Активность областей ядрышковых организаторов в трофобласте при воздействии гипоксии. Морфология, 2007, т. 132, вып. 4, с. 64-67.
  4. Серов В.В. и Шехтер А.Б. Соединительная ткань (функциональная морфология и общая патология). М., Медицина, 1981.
  5. Тиктинский О.Л. Новиков И.Ф. и Михайличенко В.В. Заболевания половых органов у мужчин. Л., Медицина, 1985.
  6. Штейн Г.И. и Кудрявцев Б.Н. Морфометрическое исследование окрашенных серебром ядрышек в одноядерных и двуядерных гепатоцитах крысы. Цитология, 1997, т. 39, № 9, с. 775-782.
  7. Akkus E., Carrier S., Baba K. et al. Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence. Br. J. Urol., 1997, v. 79, p. 47-53.
  8. Aversa A., Rossi F., Francomano D. et al. Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users. Int. J. Impot. Res., 2008, v. 20, p. 566-573.
  9. Bacon C.G., Mittleman M.A., Kawachi I. et al. Sexual function in men older than 50 years of age: results from the Health Professionals Follow-up Study. Ann. Intern. Med., 2003, v. 139, p. 161-168.
  10. Brock G., Hsu G.L., Nunes L. et al. The anatomy of the tunica albuginea in the normal penis and Peyronie's disease. J. Urol., 1997, v. 157, № 1, р. 276-281.
  11. Conti G. and Virag R. Human penile erection and organic impotence: normal histology and histopathology. Urol. Int., 1989, v. 44, № 5, p. 303-308.
  12. Daskal Y., Smetana K. and Busch H. Evidence from studies on segregated nucleoli that nucleolar silver proteins C 23 and B 23 are in the fibrillar components. Exp. Cell Res., 1980, v. 127, р. 285-291.
  13. Mulhall J.P. and Damaser M.S. Development of a mathematical model for the prediction of the areas of venous leak. Int. J. Impot. Res., 2001, v. 13, № 4, p. 236-239.
  14. Nadji M. and Morales A.R. Immunoperoxidase, part I: the techniques and pitfalls. Lab. Med., 1983, v. 14, p. 767-770.
  15. Thurmond F. and Trotter J. Morphology and biomechanics of the microfibrillar network of sea cucumber dermis. J. Exp. Biol., 1996, v. 199, i. 8, p. 1817-1828.
  16. Wespes E. Smooth muscle pathology and erectile dysfunction. Int. J. Impot. Res., 2002, v. 14, p. 17-20.

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