THE PECULIARITIES OF RAT TISSUE REACTIONS TO INTRAPERITONEAL IMPLANTS MADE OUT OF BIODEGRADABLE POLYHYDROXYALKANOATES



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The reaction of rat tissues to intraperitoneal placement of implants made out of biodegradable polyhydroxyalkanoates (PHA), was studied at different time points after the operation by the methods of light microscopy. It was found that after intraperitoneal PHA implant placement, the active adhesive process started leading to formation of fibrous adhesions between PHA implants and intestinal loops. When PHA implants were used in the form of films, they became surrounded by a thick fibrous capsule. As a result of PHA implant placement in the form of ultrathin fibers, the extensive foreign body granulomas with perifocal inflammation and sclerosis of surrounding tissues were formed. In these granulomas the polymer fragmentation and phagocytosis by macrophages with formation of giant cells of foreign body occured. It is concluded that PHA implants are not biodegradable and induce tissue reactions similar to those caused by other foreign bodies.

References

  1. Гаврилин В.Н. и Шкурупий В.А. Влияние накопления поливинилпирролидона в синусоидальных клетках печени на характер токсического повреждения органа. Бюл. СО РАМН, 1995, № 2, с. 24-28.
  2. Майбородин И.В., Ковынцев Н.Н. и Добрякова О.Б. Нарушения микроциркуляции как причина капсулярной контрактуры после увеличивающей маммопластики. Хирургия, 2007, № 3, с. 49-53.
  3. Шишацкая Е.И., Войнова О.Н., Горева А.В. и др. Реакция тканей на имплантацию микрочастиц из резорбируемых полимеров при внутримышечном введении. Бюл. экспер. биол., 2007, т. 144, № 12, с. 635-639.
  4. Caffee H.H., Hardt N.S. and Torre la G. Detection of breast implant rupture with aspiration cytology. Plast. Reconstr. Surg., 1995, v. 95, № 7, p. 1145-1149.
  5. Coskun S., Korkusuz F. and Hasirci V. Hydroxyapatite reinforced poly (3-hydroxybutyrate) and polyt3-hydroxybutyrate-co3-hydroxyvalerate) based degradable composite bone plate. J. Biomat. Sci. Polymer Ed., 2005, v. 16, p. 1485-1502.
  6. Englert H., Joyner E., McGill N. et al. Women's health after plastic surgery. Intern. Med. J., 2001, v. 31, № 2, p. 77-89.
  7. Ersek R.A. and Beisang A.A. 3rd. Bioplastique: a new textured copolymer microparticle promises permanence in soft-tissue augmentation. Plast. Reconstr. Surg., 1991, v. 87, № 4, p. 693-702.
  8. Greene W.B., Raso D.S., Walsh L.G. et al. Electron probe microanalysis of silicon and the role of the macrophage in proximal (capsule) and distant sites in augmentation mammaplasty patients. Plast. Reconstr. Surg., 1995, v. 95, № 3, p. 513-519.
  9. Hodgkinson D.J. Buckled upper pole breast style 410 implant presenting as a manifestation of capsular contraction. Aesthetic Plast. Surg., 1999, v. 23, № 4, p. 279-281.
  10. Kaiser W. and Zazgornik J. Does silicone induce autoimmune diseases? Review of the literature and case reports. J. Rheumatol., 1992, v. 51, № 1, p. 31-34.
  11. Miro-Mur F., Hindié M., Kandhaya-Pillai R. et al. Medicalgrade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells. J. Biomed. Mater. Res. B Appl. Biomater., 2009, v. 90, № 2, p. 510-520.
  12. Raso D.S., Greene W.B., Harley R.A. and Maize J.C. Silicone deposition in reconstruction scars of women with silicone breast implants. J. Am. Acad. Dermatol., 1996, v. 35, № 1, p. 32-36.
  13. Rodriguez A. and Anderson J.M. Evaluation of clinical biomaterial surface effects on T lymphocyte activation. J. Biomed. Mater. Res. A., 2010, v. 92, № 1, p. 214-220.
  14. Rodriguez A., Meyerson H. and Anderson J.M. Quantitative in vivo cytokine analysis at synthetic biomaterial implant sites. J. Biomed. Mater. Res. A., 2009, v. 89, № 1, p. 152-159.
  15. Rouanet P., Duchene M. and Quenet F. Cancer update on breast reconstruction. Bull. Cancer, 2002, v. 89, № 1, p. 125-129.
  16. Ruot-Worley J. Augmentation mammoplasty: implications for the primary care provider. J. Am. Acad. Nurse Pract., 2001, v. 13, № 7, p. 304-309.
  17. Shishatskaya E.I., Voinova O.N., Goreva A.V. et al. Biocompatibility of polyhydroxybutyrate microspheres: in vitro and in vivo evaluation. J. Mater. Sci. Mater. Med., 2008, v. 19, № 6, p. 2493-2502.
  18. Sudesh K. Microbial polyhydroxyalkanoates (PHAs): an emerging biomaterial for tissue engineering and therapeutic applications. Med. J. Malaysia, 2004, v. 59, p. 55-66.
  19. Volova T.G., Gladyshev M.I., Trusova M.Y. et al. Degradation of bioplastics in natural environment. Dokl. Biol. Sci., 2004, v. 397, p. 330-332.
  20. Zeller J.M. Surgical implants. Physiological response. AORN J., 1983, v. 37, № 7, p. 1284-1291.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2011 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies