急性应激状态下大鼠胃黏膜脂质平衡的变化

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论证。应激性溃疡是一种胃粘膜病变，是对严重的生理或心理压力的反应。然而，人们对这类溃疡的一些关键病因机制仍然知之甚少。

本研究旨在评估急性应激状态下大鼠胃黏膜的脂质组成。

材料和方法。参与研究的大鼠（n=30）分为两组。第 1 组（主要组，n=20）用电脉冲刺激动物 12 小时，制作应激性胃溃疡模型。第 2 组（对照组，n=10）未进行任何操作。实验结束后，测定所有动物血清中白蛋白的有效浓度和总浓度，然后计算其结合储备量和血浆毒性指数。此外，还目测了胃黏膜的损伤程度，并测定了其中的脂质成分。

结果。我们的研究表明，应激情况导致第 1 组动物出现内源性中毒。应激大鼠的磷脂酰胆碱浓度降低了 16.3%，磷脂酰丝氨酸浓度降低了 18.6%，这表明细胞膜受到了破坏。宏观上表现为胃黏膜点状出血、糜烂和溃疡。第 1 组动物的单酰甘油浓度增加了 34.4%，二酰甘油浓度增加了 53.4%，这表明膜的渗透性增加并诱导了再生过程。

结论。压力导致的状态有利于降低白蛋白的总浓度和有效浓度。因此，会出现内源性中毒，导致脂质失衡，并不排除对细胞膜的损害。此外，还会对胃黏膜造成急性损伤。

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作者简介

Tatyana V. Tarasova

National Research Ogarev Mordovia State University

Email: 9023060@mail.ru
ORCID iD: 0000-0001-9745-9739
SPIN 代码: 1726-3994

Dr. Sci. (Biology), Professor

俄罗斯联邦, 68 Bol'shevistskaja street, 430005 Saransk

Larisa M. Mosina

National Research Ogarev Mordovia State University

Email: larisamosina97@yandex.ru
ORCID iD: 0000-0001-6831-3116
SPIN 代码: 2390-1111

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, 68 Bol'shevistskaja street, 430005 Saransk

Roman S. Tarasov

National Research Ogarev Mordovia State University

Email: trs4334@yandex.ru
ORCID iD: 0000-0002-5598-5033
SPIN 代码: 3358-5958

Cand. Sci. (History), Assistant Professor

俄罗斯联邦, 68 Bol'shevistskaja street, 430005 Saransk

Marina V. Esina

National Research Ogarev Mordovia State University

Email: esina.marina.val@yandex.ru
ORCID iD: 0000-0002-5318-2966
SPIN 代码: 8753-5294

MD, Cand. Sci. (Medicine), Assistant Professor

俄罗斯联邦, 68 Bol'shevistskaja street, 430005 Saransk

Dalila A. Khaydar

Peoples' Friendship University of Russia

Email: dalila96-96@mail.ru
ORCID iD: 0000-0002-5490-1037

MD

俄罗斯联邦, Moscow

Andrey V. Kuchuk

Peoples' Friendship University of Russia

Email: kuchuk-av@rudn.ru
ORCID iD: 0000-0002-3807-1352
SPIN 代码: 9089-7090

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Moscow

Ekaterina A. Khodzhaeva

Peoples' Friendship University of Russia

编辑信件的主要联系方式.
Email: 1032211689@pfur.ru
ORCID iD: 0009-0004-8729-3500

MD

俄罗斯联邦, Moscow

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2. Fig. 1. Distribution of the number of destructive lesions of the gastric mucosa in animals after stress.

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3. Fig. 2. The values of the Pauls index depending on the type of lesion of the gastric mucosa.

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4. Fig. 3. Indicators of endogenous intoxication in blood plasma in animals of both groups; * p <0.05 when comparing the indicators of groups 1 and 2.

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5. Fig. 4. Lipid concentration (mg/ml) in the stomach wall in animals of groups 1 and 2; * p <0.05 when comparing the indicators of groups 1 and 2.

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