Email this article THE CYTOARCHITECTONICS AND NEURONAL ORGANIZATION OF THE BASOLATERAL NUCLEUS OF THE AMYGDALA OF THE BRAIN IN ALCOHOL-PREFERRING AND ALCOHOL-NONPREFERRING RATS
- Authors: Akhmadeyev A.V.1, Kalimullina L.B.1
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Affiliations:
- Bashkir State University
- Issue: Vol 150, No 4 (2016)
- Pages: 20-23
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/397729
- DOI: https://doi.org/10.17816/morph.397729
- ID: 397729
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Abstract
Analysis of cytoarchitectonics of the basolateral nucleus (BLN) of the brain amygdala was performed in cresyl violet-stained frontal paraffin sections of the brain in 10 alcohol-preferring (AP) and 10 alcohol-nonpreferring (ANP) rats (with an equal number of male and female animals in each group). The presence of large and small neurons was detected in BLN. Most of the large neurons in AP rats had the character of chromoneutral and moderately chromophilic cells, while in ANP rats these cells were moderately chromophobic. Application of Golgi method demonstrated that the equivalents of large neurons were long-axonal densely branched pyramid-like neurons, and those of small-sized neurons - short-axonal neurons. The determination of the ratio of large and small-sized neurons showed that in AP rats the proportion of latter was 12.3±0.6%, while in the ANP rats it was significantly greater - 19.70±0.23%. These results help to explain the previously obtained data on larger specific area of BLN in amygdala of ANP rats by the presence of greater number of interneurons than in AP rats.
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About the authors
A. V. Akhmadeyev
Bashkir State University
Email: mpha@ufanet.ru
L. B. Kalimullina
Bashkir State University
References
- Ахмадеев А. В., Федорова А. М., Калимуллина Л. Б. Структурно-количественная характеристика миндалевидного тела и первичной соматосенсорной коры мозга предпочитающих и не предпочитающих алкоголь крыс // Морфология. 2014. Т. 145, вып. 1. С. 19-23.
- Леонтович Т. А. Нейронная организация подкорковых образований переднего мозга. М.: Медицина, 1978.
- Bienvenu T. C., Busti D., Magill P. J. et al. Cell-type-specific re cruitment of amygdale interneurons to hippocampal theta rhythm and noxious stimuli in vivo // Neuron. 2012. Vol. 20, № 6. P. 1059-1074.
- Bissonette G. B., Bae M. H., Suresh T. et al. Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons // Behav. Brain Res. 2014. Vol. 259, № 3. P. 143-151.
- Chu H. Y., Ito W., Li J., Morozov A. Target-specific suppression of GABA release from parvalbumin interneurons in the basolateral amygdale by dopamine // J. Neurosci. 2012. Vol. 32, № 42. P. 14815-14820.
- De la Mora M. P., Gallegos-Cari A., Arizmendi-García Y. et al. Role of dopamine receptor mechanisms in the amygdaloid modulation of fear and anxiety: Structural and functional analysis // Prog. Neurobiol. 2010. Vol. 90, № 2. P. 198-216.
- Einarson L., Krogh E. Variation in the basophilia of nerve cells associated with increased cell activity and functional stress // J. Neurol. Neurosurg. Psychiatry. 1955. Vol. 18. P. 1-12.
- McDonald A. J., Muller J. F., Mascagni F. Postsynaptic targets of GABAergic basal forebrain projections to the basolateral amygdala // Neuroscience. 2011. Vol. 183, № 2. P. 144-159.
- Muller J. F., Mascagni F., McDonald A. J. Pyramidal cells of the rat basolateral amygdala: synaptology and innervation by parvalbumin-immunoreactive interneurons // J. Comp. Neurol. 2006. Vol. 494, № 4. P. 635-650.
- Pandey S. C. Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene // Trends Pharmacol. Sci. 2003. Vol. 24, № 9. P. 456-460.
- Spampanato J., Polepalli J., Sah P. Interneurons in the basolateral amygdala // Neuropharmacology. 2011. Vol. 60, № 5. P. 765-773.
- Stafford J. M., Maughan D. K., Ilioi E. C., Lattal K. M. Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal - amygdalar circuits // Learn Mem. 2013. Vol. 20, № 3. P. 156-163.
- Szinyei C., Narayanan R. T., Pape H. C. Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice // Eur. J. Neurosci. 2007. Vol. 25, № 4. P. 1205-1216.
- Toufexis D. Region- and sex-specific modulation of anxiety behaviours in the rat // J. Neuroendocrinol. 2007. Vol. 19, № 6. P. 461-473.
- Woodruff A. R., Sah P. Networks of parvalbumin-positive interneurons in the basolateral amygdala // J. Neurosci. 2007. Vol. 27, № 3. P. 553-563.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).