Email this article GENDER-RELATED PECULIARITIES OF THE MYOCARDIAL REGENERATIVE CAPACITIES IN EXPERIMENTAL CARDIAC FAILURE
- Authors: Liskova Y.V.1, Stadnikov A.A.1, Salikova S.P.2
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Affiliations:
- Orenburg State Medical University
- S. M. Kirov Military Medical Academy
- Issue: Vol 152, No 5 (2017)
- Pages: 40-44
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398145
- DOI: https://doi.org/10.17816/morph.398145
- ID: 398145
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Abstract
Myocardium of the left ventricle was studied in rats (n=40) of both sexes with an experimental heart failure (HF) using light microscopy, immunocytochemistry and morphometry. The substantial reorganization of the muscular and stromal elements of the myocardium was found in animals with HF. Both remodeling and regenerative capacities of the myocardium in animals with HF demonstrated gender-associated peculiarities. Gender-related distinctions were also found in the expression of Ki-67, caspase 9 and vimentin. The role of the cardioprotective effects of estrogens on the myocardium of the left ventricle as well as the importance of other factors influencing gender-related characteristics of myocardium regeneration in HF, are discussed.
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About the authors
Yu. V. Liskova
Orenburg State Medical University
Email: liskovaj@bk.ru
Department of Histology, Cytology, and Embryology
A. A. Stadnikov
Orenburg State Medical University
Email: alexander.stadnikov@yandex.ru
Department of Histology, Cytology, and Embryology
S. P. Salikova
S. M. Kirov Military Medical Academy
Email: cardiosvet@rambler.ru
2nd Department of Therapeutics (Advanced Medical Education)
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).