Email this article ASSESSMENT OF PERIPHERAL NERVE STATE BASED ON ACETYLCHOLINESTERASE ACTIVITY
- Authors: Karapetyan A.S.1, Rumyantseva T.A1, Lebedev P.V.1
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Affiliations:
- Yaroslavl’ State Medical Academy
- Issue: Vol 146, No 6 (2014)
- Pages: 102-103
- Section: Articles
- URL: https://j-morphology.com/1026-3543/article/view/398859
- DOI: https://doi.org/10.17816/morph.398859
- ID: 398859
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Abstract
The aim of the study was to establish the possibility of assessment of the state of peripheral nerve based on acetylcholinesterase (AChE) activity. In a series of experiments on rats, the method for demonstration the of AChE activity on the sections of the peripheral nerves was modified (priority reference № 2013157128 of 23.12.13) and it was shown that the reaction intensity depended upon the state of the nerve fibers. During the atrophic processes, the enzyme activity decreased, while it was dramatically increased during fiber sprouting. It was shown that by using the intensity of AChE reaction as a criterion, the state of the nerve could be evaluated within 1-2 hours, which may be used later during the reconstructive operations (intraoperatively).
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About the authors
A. S. Karapetyan
Yaroslavl’ State Medical Academy
Email: а2311@inbox.ru
T. A Rumyantseva
Yaroslavl’ State Medical Academy
Email: rum-yar@mail.ru
P. V. Lebedev
Yaroslavl’ State Medical Academy
Email: paw.lebedeff2011@yandex.ru
References
- Куринный И. Н. Хирургическое лечение застарелой сочетанной травмы срединного и локтевого нервов: Автореф. дис. … канд. мед. наук. Киев, 1991.
- Луппа Х. Основы гистохимии. М., Мир, 1980.
- Bontioti E., Kanje M., Lundborg G. and Dahlin LB. End-to-side nerve repair in the upper extremity of rat. J. Peripher. Nerv. Syst., 2005, v. 10, № 1, p. 58-68.
- Portincasa A., Gozzo G., Parisi D. et al. Microsurgical treatment of injury to peripheral nerves in upper and lower limbs: a critical review of the last 8 years. Microsurgery, 2007, v. 27, № 5, p. 455-462.
- Terzis J. K. An Exciting New Concept in Facial Reanimation. The Facial Nerve. Amsterdam, Kugler & Ghedini Publications, 1988.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).