INTRANUCLEAR IRON DISTRIBUTION IN THE PURKINJE CELLS OF HUMAN CEREBELLUM



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The distribution of iron ions in the cerebellum of 15 human subjects aged 20-89-years was studied using highly-sensitive variant of Perls’ histochemical technique. Increased iron content was found in the white matter and in Purkinje cells. In 10 out of 15 cases examined iron was detected in the nuclei of Purkinje cells, while in some cases iron was found in the nucleolus.

Full Text

Restricted Access

About the authors

D. E. Korzhevskiy

RAS Institute of Experimental Medicine

Email: dek2@yandex.ru
Laboratory of the Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

Ye. G. Sukhorukova

RAS Institute of Experimental Medicine

Email: len48@inbox.ru
Laboratory of the Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

V. V. Gusel’nikova

RAS Institute of Experimental Medicine

Email: guselnicova.valeriia@yandex.ru
Laboratory of the Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

O. V. Kirik

RAS Institute of Experimental Medicine

Laboratory of the Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

I. P. Grigoriyev

RAS Institute of Experimental Medicine

Laboratory of the Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

References

  1. Сухорукова Е. Г., Григорьев И. П., Колос Е. А., Коржевский Д. Э. Ядрышко клетки - место накопления железа в нейронах черного вещества головного мозга человека // Морфология. 2012. Т. 142, вып. 6. С. 61-62.
  2. Bower J. M., Parsons L. M. Rethinring the lesser brain // Sci. Amer. 2003. Vol. 289, № 2. P. 51-57.
  3. Li Volti G., Ientile R., Abraham N. G. et al. Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial Cell. cultures during differentiation: effect of glutamate // Biochem. Biophys. Res. Commun. 2004. Vol. 315, № 2. P. 517- 524.
  4. Meguro R., Asano Y., Odagiri S. et al. Nonheme-iron histo chemistry for light and electron microscopy: a historical, theoretical and technical review // Arch. Histol. Cytol. 2007. Vol. 70, № 1. P. 1-19.
  5. Roschzttardtz H., Grillet L., Isaure M.-P. et al. Plant Cell nucleolus as a hot spot for iron // J. Biol. Chem. 2011. Vol. 286, № 32. P. 27863-27866.
  6. Schmahmann J. D. Cerebrocerebellar system: anatomic substrates of the cerebellar contribution to cognition and emotion // Int. Rev. Psychiatry. 2001. Vol. 13, № 2. P. 247-260.
  7. Schmahmann J. D., Caplan D. Cognition, emotion and cerebellum // Brain. 2006. Vol. 129, Pt. 2. P. 290-292.
  8. Youdim M. B., Stephenson G., Ben Shachar D. Ironing iron out in Parkinson’s disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28 // Ann. N. Y. Acad. Sci. 2004. Vol. 1012. P. 306-325.
  9. Yung B. Y., Yang Y. H., Bor A. M. Nucleolar protein B23 translocation after deferoxamine treatment in a human leukemia Cell line // Int. J. Cancer. 1991. Vol. 48, № 5. P. 779-784.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2015 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: № 0110212 от 08.02.1993.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies