REACTIVE CHANGES OF HUMAN GASTRIC MUCOSA INFECTED WITH HELICOBACTER PYLORI IN THE ASPECT OF GENETIC CHARACTERISTIC OF HOST INFLAMMATORY RESPONSE



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Abstract

The aim of this study was to determine the morphological changes of human gastric mucosa infected with Helicobacter pylori (HP) depending on polymorphism of the genes coding both interleukin-1β and interleukin-1 receptor antagonist. 106 juveniles with HP-induced chronic gastritis were studied along with 44 juveniles with gastritis, not associated with HP. In patients with HP-associated gastritis, the significant increase in epithelial proliferation and apoptosis indexes was observed. Epithelium proliferation zone was expanded in the direction of surface foveolar epithelium and into the depth of glands; pronounced lympho-plasma cell infiltration of mucosal lamina propria was observed. Cytokine gene polymorphisms were evaluated by PCR. The results suggest an association between more pronounced inflammation of gastric mucosa with the T allele of interleukin-1β C -511 C>T gene polymorphous locus (χ2 = 14.006; р = 0.001). No association was found of the interleukin1β C +3953 T gene and the variable number of tandem repeats in the 2nd introne of interleukin 1 receptor antagonist gene with morphological changes in the gastric mucosa.

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