AGE-RELATED PECULIARITIES OF THE NEURONS CONTAINING DIFFERENT TYPES OF CALCIUM-BINDING PROTEINS IN THE INTRAMURAL GANGLIA OF SMALL INTESTINE



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Abstract

Immunohistochemical and morphometric methods were used to study the localization, relative content and the cross-sectional area of calbindin (CB)- and calretinin (CR)-immunopositive neurons in the intramural ganglia of the myenteric plexus of duodenum in rats (n=37) in postnatal ontogenesis (Days 1, 10, 20, 30, 60, 1 and 2 years). CB - and CR-immunopositive neurons were detected in all the rats studied, from newborn to aged ones. The proportion of CR-immunopositive neurons was increased during the first 10 days of life, and then was not changed significantly, including the older animals. The proportion of CB-containing neurons increased, reaching a maximum value by Day 20, then declined insignificantly by Day 30 and was not significantly changing thereafter. The average size of CB- and CR-immunopositive neurons was significantly greater than the average cross-sectional area of immunoreative neurons in all age groups.

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About the authors

A. I. Yemanuilov

Yaroslavl’ State Medical Academy

K. Yu. Moiseyev

Yaroslavl’ State Medical Academy

I. V. Filippov

Yaroslavl’ State Medical Academy

P. M. Masliukov

Yaroslavl’ State Medical Academy

Email: mpm@yma.ac.ru

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