AGE-RELATED PECULIARITIES OF THE NEURONS CONTAINING DIFFERENT TYPES OF CALCIUM-BINDING PROTEINS IN THE INTRAMURAL GANGLIA OF SMALL INTESTINE



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Immunohistochemical and morphometric methods were used to study the localization, relative content and the cross-sectional area of calbindin (CB)- and calretinin (CR)-immunopositive neurons in the intramural ganglia of the myenteric plexus of duodenum in rats (n=37) in postnatal ontogenesis (Days 1, 10, 20, 30, 60, 1 and 2 years). CB - and CR-immunopositive neurons were detected in all the rats studied, from newborn to aged ones. The proportion of CR-immunopositive neurons was increased during the first 10 days of life, and then was not changed significantly, including the older animals. The proportion of CB-containing neurons increased, reaching a maximum value by Day 20, then declined insignificantly by Day 30 and was not significantly changing thereafter. The average size of CB- and CR-immunopositive neurons was significantly greater than the average cross-sectional area of immunoreative neurons in all age groups.

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作者简介

A. Yemanuilov

Yaroslavl’ State Medical Academy

K. Moiseyev

Yaroslavl’ State Medical Academy

I. Filippov

Yaroslavl’ State Medical Academy

P. Masliukov

Yaroslavl’ State Medical Academy

Email: mpm@yma.ac.ru

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