Development of thoracic aortic aneurysm: the potential role of morphological features of functional zones

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Abstract

Aneurysm is the most common pathology affecting the aorta. Advances in diagnostic and therapeutic approaches have reduced the associated mortality rate to 21.7%. Aneurysm formation involves morphological and functional remodeling of the aortic wall, leading to altered biomechanical properties of the vessel. Along the aorta, distinct functional zones with a high density of sensory receptors have been identified. These receptor zones have a specific anatomical distribution, with most sensory receptors localized in the tunica media of aorta. The vascular wall within these zones undergoes changes in lumen diameter that differ from those observed in other regions of the aorta. The morphological characteristics of these receptor-rich segments determine the unique biomechanical behavior of the vessel. The receptor zones of the aorta topographically correspond to the regions most frequently affected by aneurysm formation.

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About the authors

Andrey V. Suslov

National Medical Research Centre of Cardiology Named After Academician E.I. Chazov; The Russian National Research Medical University named after N.I. Pirogov

Author for correspondence.
Email: dr_suslov@mail.ru
ORCID iD: 0000-0003-0613-8556
SPIN-code: 8738-6986

MD, Cand. Sci. (Medicine)

Russian Federation, 15A Academician Chazova st, 121552, Moscow; Moscow

Alexey E. Strizhkov

The First Sechenov Moscow State Medical University

Email: strizhkov@inbox.ru
ORCID iD: 0000-0003-0730-347X
SPIN-code: 5450-4704

MD, Cand. Sci. (Medicine), Assistant Professor

Russian Federation, Moscow

Tatiana V. Kirichenko

National Medical Research Centre of Cardiology Named After Academician E.I. Chazov; The Russian National Research Medical University named after N.I. Pirogov

Email: t-gorchakova@mail.ru
ORCID iD: 0000-0002-2899-9202
SPIN-code: 4332-9045

MD, Cand. Sci. (Medicine)

Russian Federation, 15A Academician Chazova st, 121552, Moscow; Moscow

Petr V. Chumachenko

National Medical Research Centre of Cardiology Named After Academician E.I. Chazov

Email: chumach7234@mail.ru
ORCID iD: 0000-0002-1162-6055

MD, Cand. Sci. (Medicine)

Russian Federation, 15A Academician Chazova st, 121552, Moscow

Zukhra B. Khasanova

National Medical Research Centre of Cardiology Named After Academician E.I. Chazov

Email: zukhra@yandex.ru
ORCID iD: 0000-0002-4689-7955
SPIN-code: 5120-5137
Russian Federation, 15A Academician Chazova st, 121552, Moscow

Anton Yu. Postnov

National Medical Research Centre of Cardiology Named After Academician E.I. Chazov; Petrovsky National Research Centre of Surgery

Email: anton-5@mail.ru
ORCID iD: 0000-0002-2501-7269
SPIN-code: 3991-1357

MD, Dr. Sci. (Medicine)

Russian Federation, 15A Academician Chazova st, 121552, Moscow; Moscow

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2. Fig. 1. Functional zones of the aorta: 1, ventral surface of the aortic arch; 2, origin of the brachiocephalic trunk; 3, origin of the left subclavian artery; 4, region of the ligamentum arteriosum.

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