THE ROLE OF E-CADHERIN CELL ADHESION MOLECULE IN HUMAN ONTOGENESIS IN NORM AND PATHOLOGY



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Abstract

E-cadherin is one of the most important cell adhesion molecules, which plays a key role in embryogenesis and adult tissues under normal conditions and during tumor development. Molecules of E-cadherin are located at the epitheliocyte surface and take part in the adhesion contacts formation which are a characteristic feature of epithelial tissues. The role of E-cadherin is not only in the maintenance of intercellular adhesion, but also in provision of cell proliferation and differentiation through participation in the realization of a number of signaling pathways, the main of which is the canonical Wnt signaling pathway. This review provides basic information regarding the role of E-cadherin in human ontogenesis in norm and pathology

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About the authors

Yu. M. Zasadkevich

Institute of Medical Cell Technologies Centre of Rendering the Specialized Medical Aid to the Population

Email: zasadkevich@selltechnologies.ru

S. V. Sazonov

Institute of Medical Cell Technologies Centre of Rendering the Specialized Medical Aid to the Population

Email: prof-ssazonov@yandex.ru

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