Morphology

Peer-review quarterly medical journal.

 

Editor-in-chief

Publisher

About

“Morphology” journal (“Morfologiia") (previous title — Archives of Anatomy, Histology, and Embryology) is a leading morphological scientific journal which is published continuously since 1916.

The journal was founded by a prominent Russian histologist A.S. Dogiel, and for many years most distinguished Russian scientists worked in its Editorial Board, passing the baton to the modern generation of morphologists.

In the last decades the Journal is published under the auspices of the International Association of Morphologists (the successor of all-Union Scientific Society of Anatomists, Histologists, and Embryologists).

 

Types of accepted articles

  • reviews
  • systematic reviews and metaanalyses
  • original research
  • clinical case reports and series
  • letters to the editor
  • short communications
  • guidelines

Publications

  • in English and Russian
  • quarterly, 4 issues per year
  • continuously in Online First
  • with NO Article Processing Charges (APC)
  • distribution in hybrid mode - by subscription and/or Open Access
    (OA articles with the Creative Commons Attribution 4.0 International License (CC BY 4.0))

Indexation

  • Russian Science Citation Index (Web of Science)
  • Russian Science Electronic Library (eLibrary.ru)
  • Google Scholar
  • Ulrich's Periodicals directory
  • WorldCat
  • Crossref

Announcements More Announcements...

 

Eco-Vector is a new publisher of the 'Morphology' journal

Posted: 28.02.2022

The Eco-Vector publishing house became the publisher of the journal 'Morphology' (ISSN 1026-3543 (Print)). The journal is undergoing re-registration in Roskomnadzor and continues to be published quarterly in Open Access under the strict scientific guidance of the editor-in-chief and the entire editorial board.

Mass media registration certificate PI No. № 0110212 dated 08.02.1993.


 

Current Issue

Open Access Open Access  Restricted Access Access granted  Restricted Access Subscription or Fee Access

Vol 161, No 2 (2023)

Cover Page

Full Issue

Open Access Open Access
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Restricted Access Subscription or Fee Access

Original Study Articles

Morphological features of the innervation of the rat adrenal gland adipose tissue
Chumasov E.I., Petrova E.S., Korzhevskii D.E.
Abstract

BACKGROUND: The relevance of studying adipose tissue is due to a lack of understanding of the etiology and pathogenesis of obesity and a lack of research into the endocrine function of adipose tissue. The structure, functions, and innervation characteristics of white and brown adipose tissues of the adrenal gland have received the least attention.

AIM: To determine the structure and innervation of rat adrenal adipose tissue using neuroimmunohistochemical markers.

MATERIALS AND METHODS: The innervation of the rat adrenal gland’s adipose tissue was examined using immunohistochemical reactions for PGP 9.5 protein, tyrosine hydroxylase, and synaptophysin conducted on paraffin sections (n=10).

RESULTS: Unmyelinated nerve fibers and catecholaminergic and cholinergic nerve terminal apparatuses were found in the white and brown adipose tissues of the rat adrenal gland. Parasympathetic and sympathetic postganglionic nerve fibers enter adipose tissue through arterial vessels. Remakov’s varicose axons intensely branch and form passant terminal synaptic networks, which are essential in the innervation of adipocytes in white and brown adipose tissues. Brown and mixed adipose tissues contain the most sympathetic and parasympathetic synaptic structures. Sympathetic fibers are closely connected to the arterial wall and contact brown adipocytes. Varicose axons are found in white adipose tissue, primarily surrounding arterial vessels and rarely between differentiated ring-shaped adipocytes.

CONCLUSIONS: The observed differences in sympathetic innervation of white and brown adipose tissues are because brown adipose tissue cells, unlike white adipocytes, perform a secretory function. They impact corticosteroid synthesis by the adrenal gland by producing adipokines. The findings suggest that the sympathetic nervous system controls this process.

Morphology. 2023;161(2):5-13
pages 5-13 views
Morphofunctional characteristics of the pancreas after N-acetylcysteine administration in an acute postradiation pancreatitis model
Demyashkin G.A., Dubovaya T.K., Ugurchieva D.I., Vadyukhin M.A., Akhmedova P.S., Simagina V.K.
Abstract

BACKGROUND: The development of effective nondrug and drug-based methods for protecting humans and animals from the effects of ionizing radiation remains important. A morphofunctional assessment of changes in the pancreatic parenchyma is required to determine the degree of radiosensitization of acinar cells and islet cells outside the tumor and during electron treatment of cancer of nearby organs, such as the colon and stomach.

AIM: Morphofunctional assessment of the pancreas after N-acetylcysteine administration in a model of acute radiation-induced pancreatitis.

MATERIALS AND METHODS: Wistar rats (Rattus Wistar; n=40) were divided into three experimental groups: control group I (n=10); II (n=10) — fractional irradiation with electrons in a total dose of 25 Gy; III (n=10) — administration of N-acetylcysteine before electron irradiation; and IV (n=10) — administration of N-acetylcysteine. A week after the last fraction, animals from all groups were removed from the experiment.

RESULTS: A week after electron irradiation, a disruption in histoarchitecture was found in group II due to signs of acute postradiation pancreatitis. Increases in glucose, amylase, and malondialdehyde levels were associated with decreases in insulin and superoxide dismutase levels. In group III, the depth and range of damage to the pancreas were less evident with N-acetylcysteine administration.

CONCLUSIONS: After a week of local irradiation with electrons at a total irradiation dose of 25 Gy, the histoarchitecture of the pancreas is disrupted, resulting in acute postradiation pancreatitis. N-acetylcysteine reduces the depth and range of radiation-induced damage while increasing the effectiveness of antioxidant protection.

Morphology. 2023;161(2):15-22
pages 15-22 views
The effects of dark deprivation and chronic alcohol intoxication on the liver of rats
Areshidze D.A., Kaktursky L.V., Mikhaleva L.M., Kozlova M.A.
Abstract

BACKGROUND: Nighttime exposure to artificial lighting promotes epiphyseal melatonin deficiency and disrupts the circadian cycle of most body functions in mammals. Several studies have associated these factors with the development of many liver pathologies. A considerable lack of melatonin, along with a mismatch in the daily cycle of vital processes, increases the sensitivity of the liver to alcohol-induced damage and the severity of alcoholic illness.

AIM: This study aimed to identify the combined effect of constant lighting and chronic alcohol intoxication (CAI) on the liver structure of both sexes of rats.

MATERIALS AND METHODS: TThe study was conducted on 120 male and 80 female outbred Wistar rats aged 6 months. The trial lasted for 3 weeks. Four groups of rats of each sex were formed (control group, CAI group, dark deprivation group, and group exposed to both factors). Preparations stained with hematoxylin and eosin were evaluated. Sudan III staining was used to assess the severity of fatty degeneration, and the expression of Ki-67 and p53 as markers of proliferation and apoptosis, respectively, was measured immunohistochemically.

RESULTS: Chronic alcohol intoxication and dark deprivation cause similar morphological changes in the livers of male and female rats, resulting in fatty degeneration, necrosis, and increased hepatocyte apoptotic activity. The combined effect of these factors causes more dramatic changes in the structure of the liver of males, resulting in the development of cirrhotic changes in 13.3% of them and toxic hepatitis in 20%, whereas only 5% of females show signs of alcoholic hepatitis. Increased Ki-67 expression in male hepatocytes is found only when CAI and dark deprivation are combined. However, in females, an increase in Ki-67 expression is observed both alone and when these factors are combined.

CONCLUSION: The findings allow us to conclude that female rats adapt more successfully to the independent and combined effects of CAI and dark deprivation than male rats.

Morphology. 2023;161(2):23-35
pages 23-35 views

Letters to the editor

Tissue science and histology in the system of biomedical scientific and educational disciplines
Shevlyuk N.N., Stadnikov A.A.
Abstract

In this article, the authors analyze the role and significance of histology in biomedical scientific and educational disciplines (history, present condition, and controversial issues). This study discusses the formation and development of histology—the science of tissues—and the emergence of notions about tissues and tissue classification. When describing the microscopic structure of plant organs in 1671, the English botanist and physician N. Grew (1641–1712) used the term “tissue” for the first time. In the mid-19th century, German histologists R.A. Kölliker (1817–1905) and F. Leydig (1821–1908) established the present scientific classification of tissues. These authors classified tissues into four main groups: epithelium, connective tissue and blood, nervous tissue, and muscle tissue. Russian scientists A.A. Zavarzin and N.G. Khlopin made significant contributions to developing tissue classification and evolution problems. It is worth noting that the term “tissue,” which was initially interpreted as purely morphological, has gained physiological content; that is, the idea of “tissue” has become a morphofunctional concept. The idea of tissue stability during the ontogenesis stages of organisms is one of the significant paradigms of histology. Fabric variability is allowed within certain limits within the tissue group to which the fabric belongs. There is no compelling evidence of tissue transition from one tissue group to another. The first histology departments appeared in European higher educational institutions in the middle of the 19th century and Russian higher educational institutions in the late 1960s. As a scientific discipline, histology has not exhausted its capabilities; therefore, excluding histology from the nomenclature of scientific specialization is incorrect.

Morphology. 2023;161(2):37-46
pages 37-46 views

Biography

Contribution of Vladimir Lazarevich Bykov (1947–2022) to the development of Russian histology, cytology, and embryology
Shevlyuk N.N.
Abstract

The main stages of the life and works of the renowned Russian scientist and teacher Vladimir Lazarevich Bykov are highlighted in this article. His scientific research focused on several fundamental and applied problems in histology, cytology, embryology, and pathomorphology (histophysiology of the thyroid gland, pathomorphology of various organs with candidiasis, morphofunctional characteristics of the oral cavity organs, analysis of the protective mechanisms of the mucous membranes of the digestive organs, history of morphology, and methods of teaching histology, cytology, and embryology). His library of educational literature on histology, cytology, and embryology is a modern encyclopedic body of knowledge on these academic fields. His contributions to the journal Morphology as an editorial board member (1992–2022) and editor-in-chief (2002–2016) are invaluable.

Morphology. 2023;161(2):47-54
pages 47-54 views

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